DJ001
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- CAS号:
- 2161305-12-8
- 英文名:
- DJ001
- 英文别名:
- DJ001;DJ-001,DJ001;2-Propen-1-one, 3-[(3-nitrophenyl)amino]-1-phenyl-, (2Z)-
- 中文名:
- DJ001
- 中文别名:
- 化合物DJ001;化合物 T11053
- CBNumber:
- CB25848933
- 分子式:
- C15H12N2O3
- 分子量:
- 268.27
- MOL File:
- 2161305-12-8.mol
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DJ001化学性质
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沸点:
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417.7±45.0 °C(Predicted)
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密度:
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1.297±0.06 g/cm3(Predicted)
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储存条件:
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-20°C
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溶解度:
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Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml with warming)
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形态:
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solid
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酸度系数(pKa):
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-1.30±0.70(Predicted)
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颜色:
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Yellow
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稳定性:
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Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
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DJ001性质、用途与生产工艺
DJ001 是一种高度特异性，选择性和非竞争性的蛋白酪氨酸磷酸酶-σ (PTPσ) 抑制剂，IC50 为 1.43 μM。DJ001 对其他磷酸酶无抑制活性，对蛋白质磷酸酶 5 仅有中等抑制活性。DJ001 促进造血干细胞再生。
IC50: 1.43 μM (Protein tyrosine phosphatase-σ)
DJ001 (5-1000 ng/mL; 3-7 days; BM KSL cells) treatment increases the percentages and numbers of BM KSL cells in culture compared with control cultures. DJ001 treatment also significantly increases the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells.
The BM KSL cells are irradiated with 300 cGy and placed in media (containing 20 ng/mL Thrombopoietin, 100 ng/mL stem cell factor (SCF), 50 ng/mL Flt3 ligand, TSF) with and without 1 μg/mL DJ001 for 3 days. DJ001 treatment increases recovery of BM CFCs and multipotent colony-forming unit–granulocyte erythroid monocyte megakaryocyte (CFU-GEMM) colonies compared with control cultures.
Cell Viability Assay
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Cell Line:
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BM KSL cells
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Concentration:
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5 ng/mL, 10 ng/mL, 100 ng/mL, 1000 ng/mL
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Incubation Time:
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3 days or 7 days
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Result:
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Increased the percentages and numbers of BM KSL cells. Also significantly increased the numbers of colony forming cells (CFCs) in 3 day culture of BM KSL cells.
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DJ001 (5 mg/kg; subcutaneous injection; for 24 hours; female C57BL/6 mice) significantly decreases the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI. DJ001 suppresses radiation-induced HSC apoptosis via activation of the RhoGTPase, RAC1, and induction of BCL-X
L
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Animal Model:
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Female C57BL/6 mice (8-10-week-old) irradiated with total body irradiation (TBI)
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Dosage:
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5 mg/kg
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Administration:
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Subcutaneous injection; for 24 hours
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Result:
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Significantly decreased the percentage of apoptotic BM KSL cells in C57BL/6 mice at 24 h following 500 cGy TBI.
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DJ001
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| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/04/30 | HY-133146 | DJ001 | | 1 mg | 1200元 |
| 2024/04/30 | HY-133146 | DJ001
DJ001 | 2161305-12-8 | 5mg | 2800元 |
2161305-12-8, DJ001 相关搜索:
- 抑制剂
- 化合物DJ001
- 化合物 T11053
- 2161305-12-8
- 2-Propen-1-one, 3-[(3-nitrophenyl)amino]-1-phenyl-, (2Z)-
- DJ-001,DJ001
- DJ001