2-胍基琥珀酸
中文名称 | 2-胍基琥珀酸 |
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中文同义词 | 2-胍基琥珀酸;(S)-2-胍基琥珀酸;胍基琥珀酸;L-胍基丁二酸;(S)-2-胍基丁二酸;胍丁二酸 |
英文名称 | GUANIDINOSUCCINIC ACID |
英文同义词 | (2S)-2-(diaminomethylideneamino)butanedioic acid;L-ASPARTICACID,N-(AMINOIMINOMETHYL)-;2-Guanidinosuccinic acid;(S)-GUANIDINOSUCCINIC ACID;guanidinosuccic acid;(S)-GUANIDINOSUCCINIC ACID dihydrobromide;GUANIDINOSUCCINIC ACID;N-AMIDINO-L-ASPARTIC ACID |
CAS号 | 6133-30-8 |
分子式 | C5H9N3O4 |
分子量 | 175.14 |
EINECS号 | |
相关类别 | 有机化学品;amino acids |
Mol文件 | 6133-30-8.mol |
结构式 |
2-胍基琥珀酸 性质
沸点 | 344.5±52.0 °C(Predicted) |
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密度 | 1.74±0.1 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | DMSO:1 mg/ml; PBS(pH 7.2):5 mg/ml |
形态 | 固体 |
酸度系数(pKa) | 3.22±0.23(Predicted) |
颜色 | 白色至米白色 |
Human Endogenous Metabolite
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Guanidinosuccinic acid, a constituent of normal urine, is elevated in the urine and serum of azotemic patients. Guanidinosuccinic acid (GSA), a guanidino compound found to be greatly increased in uremia, is administered by intraperitoneal (i.p.) injection to adult albino mice and to young mice 7, 14 and 21 days old. Epileptogenic and toxic properties are assessed and Guanidinosuccinic acid brain levels following i.p. injection ae determined. In adult mice, Guanidinosuccinic acid induces long-lasting generalized clonic and clonic-tonic convulsions in a dose-dependent manner with a CD 50 (and 95% confidence interval) of 363 (287-458) mg/kg (n=35), and an LD 50 of 579 (445-756) mg/kg. The CD 50 of Guanidinosuccinic acid corresponded with a brain concentration of 56 nmol/g tissue. Electrocorticographic recording in five adult mice revealed epileptiform discharges (spikes, spike-waves, and polyspike-waves) which appeared concomitant with the convulsions, When young mice are i.p. injected with a (for adults) subconvulsive dose of Guanidinosuccinic acid (250 mg/kg), an age-dependent decrease is noted in Guanidinosuccinic acid-induced convulsions and in the resulting brain concentration.
安全信息
WGK Germany | 3 |
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RTECS号 | CI9098875 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | XW613330801 | 试剂Guanidinosuccinic acid Guanidinosuccinic acid | 10mg | 386元 | |
2024/04/30 | HY-113373 | 2-胍基琥珀酸 Guanidinosuccinic acid | 6133-30-8 | 10mg | 500元 |