1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮
中文名称 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 |
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中文同义词 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮;1H-[1,2,4]恶二唑并[4,3-A]喹恶啉-1-酮;1H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-酮;1H-[1,2,4]噁二唑并[4,3-A]喹喔啉-1-酮;1H- [1,2,4]恶二唑[4,3-A]喹喔啉-1-酮;H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-酮;1H-[1,2,4]恶二唑并[4,3-A]喹喔啉-1-武汉脒祥化学酮 |
英文名称 | ODQ |
英文同义词 | ODQ;2-OXA-3,5,9B-TRIAZA-CYCLOPENTA[A]NAPHTHALENE-1-ONE;1H-[1,2,4]OXADIAZOLE[4,3-A]QUINOXALIN-1-ONE;1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE;ODQ,98%;ODQ1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one;1H-[1,2,4]Oxadiazolo[4,3-A]quinoxalin-1-one (9ci);1H-[1,2,4]OXADIAZOLO[4,3-A]QUINOXALIN-1-ONE[ODQ] |
CAS号 | 41443-28-1 |
分子式 | C9H5N3O2 |
分子量 | 187.15 |
EINECS号 | |
相关类别 | 合成;生化试剂;Cyclic Nucleotide related;Amines;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Antineoplastic;Signalling |
Mol文件 | 41443-28-1.mol |
结构式 |
1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 性质
熔点 | 160-170 °C |
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沸点 | 321.89°C (rough estimate) |
密度 | 1.3753 (rough estimate) |
折射率 | 1.6500 (estimate) |
RTECS号 | RO0913150 |
储存条件 | 2-8°C |
溶解度 | 乙醇:1.2 mg/mL |
形态 | 粉末 |
酸度系数(pKa) | 0.94±0.20(Predicted) |
颜色 | 淡黄色低 |
稳定性 | DMSO中的溶液可在-20°下稳定储存3个月。 |
CAS 数据库 | 41443-28-1(CAS DataBase Reference) |
Target | Value |
sGC
() |
At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM.
ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat.
Animal Model: | Anesthetized, male Wistar rats |
Dosage: | 2 mg/kg |
Administration: | I.p. |
Result: | Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide. |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | 32880 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98%, Thermo Scientific Chemicals | 41443-28-1 | 10mg | 1826元 |
2024/08/19 | 32880 | 1H-[1,2,4]恶草灵并[4,3-A]喹喔啉-1-酮 10MG ODQ, 98%, Thermo Scientific Chemicals | 41443-28-1 | 50mg | 7226元 |