N-乙酰-5-羟色胺
中文名称 | N-乙酰-5-羟色胺 |
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中文同义词 | N-乙酰-5-羟色胺;N-乙酰基血清素;N-乙酰-5-羟基色胺;N-乙酰-5-羟基色胺;N-乙酰羟色胺;N-乙酰基-5-羟基色胺;羟色胺杂质5;N-(2-(5-羟基-1H-吲哚-3-基)乙基)乙酰胺 |
英文名称 | N-ACETYL-5-HYDROXYTRYPTAMINE |
英文同义词 | N-Acetyl-5-hydroxytryptamine, 3-(N-Acetyl-2-aminoethyl)-5-hydroxyindole, 98%;N-Acetyl-5-hydroxytryptamine,N-Acetylserotonin, Normelatonin;3-(2-Acetamidoethyl)-5-hydroxyindole N-Acetylserotonin;N-Acetylserotonin, Normelatonin;Acetylserotonin;N-Acetyl-5-HT;N-Acetyl-5-hydroxy-1H-indole-3-ethaneamine;N-Acetyl-5-hydroxytryptamine,99% |
CAS号 | 1210-83-9 |
分子式 | C12H14N2O2 |
分子量 | 218.25 |
EINECS号 | 214-916-5 |
相关类别 | 化学试剂;试剂和补充物;小分子抑制剂;杂环化合物;对照品;其他生化试剂;药物杂质及中间体;Various Metabolites and Impurities;Tryptamines;Amino Acids;Heterocyclic Compounds;Indoles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 1210-83-9.mol |
结构式 | ![]() |
N-乙酰-5-羟色胺 性质
熔点 | 120-122 °C (lit.) |
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沸点 | 556.8±40.0 °C(Predicted) |
密度 | 1.268±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 乙醇:50 mg/mL |
酸度系数(pKa) | 10.09±0.40(Predicted) |
形态 | 粉末 |
颜色 | 白色 |
稳定性 | 吸湿性 |
CAS 数据库 | 1210-83-9(CAS DataBase Reference) |
Target | Value |
TrkB receptor
() |
N-Acetyl-5-hydroxytryptamine (NAS), a precursor of Melatonin, is acetylated from serotonin by AANAT (arylalkylamine N-acetyltransferase). N-acetylserotonin activates TrkB receptor in a circadian rhythm. N-Acetyl-5-hydroxytryptamine swiftly activates TrkB in a circadian manner and exhibits antidepressant effect in a TrkB-dependent manner. N-Acetyl-5-hydroxytryptamine rapidly activates TrkB, but not TrkA or TrkC, in a neurotrophin- and MT3 receptor-independent manner.
To explore whether N-Acetyl-5-hydroxytryptamine, can trigger TrkB activation in vivo, TrkB F616A knockin mice are employed, where it has been shown that TrkB F616A activation can be selectively blocked by 1NMPP1, a derivative of kinase inhibitor PP1, leading to TrkB-null phenotypes. To assess whether N-Acetyl-5-hydroxytryptamine can mimic BDNF, cortical neurons from TrkB F616A knockin mice are prepared. In alignment with a previous report, BDNF- and NAS-mediated TrkB phosphorylation are selectively reduced by 1NMPP1 but not by K252a, whereas serotonin or Melatonin had no effect . These findings suggest that NAS strongly provokes both wild-type TrkB and TrkB F616A tyrosine phosphorylation and activation.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
海关编码 | 29339900 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-107854 | N-Acetyl-5-hydroxytryptamine | 5 mg | 285元 | |
2024/08/19 | HY-107854 | N-乙酰-5-羟色胺 N-Acetyl-5-hydroxytryptamine | 1210-83-9 | 10mM * 1mLin DMSO | 313元 |