昔美酸沙美特罗
| 中文名称 | 昔美酸沙美特罗 |
|---|---|
| 中文同义词 | 苯磺阿曲库铵;葛兰素威;昔美酸沙美特罗;甲醇中沙米特罗溶液标准物质;沙美特罗羟萘甲酸盐:昔美酸沙美特罗;沙美特罗羟萘甲酸盐/2-羟甲基-4-[1-羟基-2-[6-(4-苯基丁氧基)己基氨基]乙基]苯酚 1-羟基-2-萘甲酸盐;2-羟甲基-4-[1-羟基-2-[6-(4-苯基丁氧基)己基氨基]乙基]苯酚 1-羟基-2-萘甲酸盐;沙美特罗羟萘甲酸盐 |
| 英文名称 | Salmeterol xinafoate |
| 英文同义词 | (+/-) 4-HYDROXY-A1-[[[6-(4-PHENYLBUTOXY)HEXYL]AMINO]M-ETHYL]-1,3-BENZENEDIMETHANOL XINAFOATE;GR 33343X XINAFOATE;Arial;GR-33343G;Salmetedur;Salmeterol, 1-Hydroxy-2-naphthoate;1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, (+-)-, 1-hydroxy-2-naphthalenecarboxylate (salt);1,3-Benzenedimethanol, 4-hydroxy-a1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-, 1-hydroxy-2-naphthalenecarboxylate (salt) (9CI) |
| CAS号 | 94749-08-3 |
| 分子式 | C36H45NO7 |
| 分子量 | 603.74 |
| EINECS号 | |
| 相关类别 | 分析标准品;其他科研原料药;小分子抑制剂，天然产物;医药原料;医药原料药;Active Pharmaceutical Ingredients;原料药;Intermediates & Fine Chemicals;Pharmaceuticals;平喘药;中药对照品;标准品;原料;医用原料;化学试剂;API;Adrenoceptor;Amines;Aromatics;Stable Isotopes;Inhibitors |
| Mol文件 | 94749-08-3.mol |
| 结构式 |  |
昔美酸沙美特罗 性质
| 熔点 | 137-138°C |
|---|---|
| 储存条件 | 2-8°C |
| 溶解度 | H2O：微溶 |
| 形态 | 固体 |
| 颜色 | 白色 |
| Merck | 14,8337 |
| InChIKey | XTZNCVSCVHTPAI-UHFFFAOYSA-N |
| CAS 数据库 | 94749-08-3(CAS DataBase Reference) |
Salmeterol Xinafoate是一种长效的β2-adrenergic receptor激动剂，具有抗炎作用，用于哮喘症状和慢性阻塞性肺疾病（COPD）症状的治疗。
| Target | Value |
| β2-adrenergic receptor |
Salmeterol (0.001-25 µM) inhibits human T lymphocyte proliferation.
Cell Proliferation Assay
| Cell Line: | Human T lymphocytes (THP-1 cells) |
| Concentration: | 0.001, 0.01, 0.05, 0.2, 1, 5, and 25 µM |
| Incubation Time: | |
| Result: | The proliferation of Th2 cells was inhibited in a concentration dependent manner. |
Salmeterol (0.16 mg/kg), Formoterol (0.32 mg/kg) and combined treatment have therapeutic effects in mice with chronic obstructive pulmonary disease (COPD).
| Animal Model: | Male C57BL/6 mice (6-8 weeks old, body weight: 32-35 g) |
| Dosage: | Salmeterol (0.16 mg/kg) and/or Formoterol (0.32 mg/kg) |
| Administration: | The therapeutic efficacy of co-treatment was investigated in this model over a 56-day-long observation period. |
| Result: | COPD assessment test scores were markedly improved in mice with COPD. |
用途
用于治疗哮喘和慢性、梗阻性肺病用途
用于哮喘的长期治疗和支气管痉挛、可逆性气道阻塞的预防安全信息
| 危险品标志 | Xi |
|---|---|
| 危险类别码 | 36/37/38 |
| 安全说明 | 22-24/25-36-26 |
| WGK Germany | 3 |
| RTECS号 | QJ1970500 |
| 海关编码 | 2922504500 |
| 提供商 | 语言 |
|---|---|
|
英文
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昔美酸沙美特罗 化学药品说明书
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | 46217 | 昔美酸沙美特罗 Salmeterol xinafoate | 94749-08-3 | 100mg | 2101元 |
| 2024/11/08 | 46217 | 昔美酸沙美特罗 Salmeterol xinafoate | 94749-08-3 | 500mg | 6389元 |
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