西他苯
| 中文名称 | 西他苯 |
|---|---|
| 中文同义词 | 西他苯 |
| 英文名称 | CETABEN |
| 英文同义词 | CETABEN;HEXADECYLAMINO-P-AMINO BENZOIC ACID;Peroxisome Proliferator, Cetaben;Benzoic acid, 4-(hexadecylamino)-;proliferator,peroxisome,cholesterol,exceptional,triglycerides,Inhibitor,Cetaben,inhibit,non-fibrate,hypolipidemic,PPARα,drug |
| CAS号 | 55986-43-1 |
| 分子式 | C23H39NO2 |
| 分子量 | 361.56 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 55986-43-1.mol |
| 结构式 |  |
西他苯 性质
| 沸点 | 503.4±33.0 °C(Predicted) |
|---|---|
| 密度 | 0.979±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 乙醇中≤1mg/ml；DMSO 中≤20mg/ml；二甲基甲酰胺中≤20mg/ml |
| 形态 | 结晶固体 |
| 酸度系数(pKa) | 4.76±0.10(Predicted) |
| 颜色 | 白色至米白色 |
Cetaben 是一种不依赖 PPARα 的过氧化物酶体增殖物。Cetaben 是一种非纤维化降血脂药，可有效降低胆固醇和甘油三酸酯的浓度。
Cetaben (10 µM; 24 hours) induces severe micromorphological and ultrastructural changes in HepG2 and MH1C1 cells. After treatment with 100 µM cetaben, cells contained several Golgi regions, most of them disintegrated into vesicles.
Cetaben-treated (10 µM; 24 hours) cells were characterized by a striking heterogeneity of the peroxisomal population with the occurrence of dumbbell-shaped and cup-shaped peroxisomal profiles in MH1C1cells.
Cetaben reveales a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect is observed at 250 mg/kg.
| Animal Model: | Male Wistar rats |
| Dosage: | 10,25,50,100,250 and 500 mg/kg |
| Administration: | Gavage; 10 day |
| Result: | Revealed a significant rise in the activities of peroxisomal enzymes in both the liver and kidney at doses of 50-100 mg/kg body over 10 days, but the maximal effect was observed at 250 mg/kg. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 5mg | 500元 |
| 2024/11/08 | HY-119964 | 西他苯 Cetaben | 55986-43-1 | 10mM * 1mLin DMSO | 550元 |