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DERAMCICLANE

DERAMCICLANE Suppliers list
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine
CAS:120444-71-5
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-20682
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Deramciclane;EGIS-3886
CAS:120444-71-5
Purity:98.00% Package:100 mg;500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Shaanxi Dideu Medichem Co. Ltd
Tel: +86-029-89586680 +86-18192503167
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Products Intro: Product Name:DERAMCICLANE
CAS:120444-71-5
Purity:99.00% Package:25kgs/Drum;200kgs/Drum Remarks:ISO 9001:2015 REACH Approved Manufacturer
Company Name: TargetMol Chemicals Inc.
Tel:
Email: support@targetmol.com
Products Intro: Product Name:Deramciclane
CAS:120444-71-5
Package:25mg;1080USD|100mg;1990USD|50mg;1410USD
Company Name: LEAPCHEM CO., LTD.
Tel: +86-852-30606658
Email: market18@leapchem.com
Products Intro: Product Name:Deramciclane
CAS:120444-71-5
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0

DERAMCICLANE manufacturers

  • Deramciclane
  • Deramciclane pictures
  • $1080.00 / 25mg
  • 2024-10-28
  • CAS:120444-71-5
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  • Supply Ability: 10g
DERAMCICLANE Basic information
Product Name:DERAMCICLANE
Synonyms:DERAMCICLANE;DERAMCLCLANE;N,N-dimethyl-2-(((1S,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;N,N-Dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]ethanamine;N,N-Dimethyl-2-(((1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]heptan-2-yl)oxy)ethanamine;EGIS-3886;Ethanamine, N,N-dimethyl-2-[[(1R,2S,4R)-1,7,7-trimethyl-2-phenylbicyclo[2.2.1]hept-2-yl]oxy]-;N,N-dimethyl-2-[[(1R,3S,4R)-4,7,7-trimethyl-3-phenyl-3-bicyclo[2.2.1]heptanyl]oxy]ethanamine
CAS:120444-71-5
MF:C20H31NO
MW:301.47
EINECS:
Product Categories:
Mol File:120444-71-5.mol
DERAMCICLANE Structure
DERAMCICLANE Chemical Properties
Boiling point 375.2±25.0 °C(Predicted)
density 1.01±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pkapKa 9.61±0.03(H2O t=25±0.1 I=0.1(NaCl)) (Uncertain)
form Oil
color Light yellow to yellow
Safety Information
MSDS Information
DERAMCICLANE Usage And Synthesis
in vitro

Deramciclane is a novel anxiolytic agent that binds with high affinity to 5-HT 2A / 2C receptors. The interactions of Deramciclane with the serotonin 5-HT 2C receptor are further characterized using receptor phosphoinositide hydrolysis assays and receptor autoradiography. Deramciclane antagonizes 5-HT 2C receptor mediated 5-HT-stimulated phosphoinositide hydrolysis with an IC 50 value of 168 nM. Deramciclane also decreases basal phosphoinositide hydrolysis by up to 33% (EC 50 = 93 nM) in a physiological system in the choroid plexus, suggesting that Deramciclane possesses inverse agonist properties at this receptor.

in vivo

Deramciclane 3 and 10 mg/kg does not change the dopamine levels significantly at any time point versus the basal level whereas 30 mg/kg of Deramciclane significantly increases the levels at 40-100 min and at 160-240 min (P<0.05). Deramciclane is a putative antiserotonergic compound that reduces 5-HT-induced phosphoinositol hydrolysis and a variety of actions caused by serotonergic agonists. The receptor binding profile of Deramciclane is rather similar to that of ritanserin. Deramciclane has a high affinity for 5-HT 2A and 5-HT 2C receptors; it acts as an antagonist at both receptor subtypes and has inverse agonist properties at the 5-HT 2C < /sub> receptors without direct stimulatory agonist effects. Deramciclane has been shown to have anxiolytic-like activity in several animal tests.

DERAMCICLANE Preparation Products And Raw materials
Raw materialsPhenylborneol
Tag:DERAMCICLANE(120444-71-5) Related Product Information
Naphthenic oil (+/-)-ISOBORNYL METHYL ETHER DERAMCICLANE 1-PHENYL-1-CYCLOPENTANOL 2-METHYLISOBORNEOL DL-Isoborneol 2,2-DIMETHYL-1-PHENYL-1-PROPANOL CYCLOPENTYLPHENYLMETHANOL 1-PHENYLCYCLOHEXANOL

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