N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺
| 中文名称 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 |
|---|---|
| 中文同义词 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 |
| 英文名称 | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro- |
| 英文同义词 | 2-Pyridinecarboxamide, N-[2-(diethylamino)ethyl]-5-fluoro-;Melanin probe-1;N-(2-(Diethylamino)ethyl)-5-fluoropicolinamide;N-[2-(diethylamino)ethyl]-5-fluoropyridine-2-carboxamide |
| CAS号 | 1420844-62-7 |
| 分子式 | C12H18FN3O |
| 分子量 | 239.29 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1420844-62-7.mol |
| 结构式 |  |
N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 性质
| 沸点 | 370.3±37.0 °C(Predicted) |
|---|---|
| 密度 | 1.102±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/mL（1044.76 mM） |
| 酸度系数(pKa) | 13.30±0.46(Predicted) |
| 形态 | 油状物 |
| 颜色 | 浅黄至黄色 |
Melanin probe-1 是一种基于 18 F-吡啶酰胺的 PET 探针。Melanin probe-1 可用于恶性黑色素瘤的 PET 显像。Melanin probe-1 具有较高的肿瘤靶向性、良好的肿瘤影像学对比，理想的生物分布模式和体内稳定性好。
Melanin probe-1 (3.7 MBq; tail vein) exhibits high tumor targeting efficiency.
Melanin probe-1 shows high in vivo stability and favorable pharmacokinetic properties such as fast clearance from urinal system and almost background level of uptakes for all of the major organs at 2 h. The high selectivity and specificity of Melanin probe-1, as evidenced by the high tumor-to-non tumor ratios, highlight that Melanin probe-1 PET has high potential to improve the melanoma detection.
| Animal Model: | C57BL/6 mice bearing B16F10 murine melanomas |
| Dosage: | 3.7 MBq (100 μCi) |
| Administration: | Tail vein |
| Result: | The tumor uptakes of Melanin probe-1 were 12.74 ± 1.70, 16.61 ± 2.60, and 16.87 ± 1.23 %ID/g at 0.5, 1, and 2 h, respectively. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 5mg | 1500元 |
| 2024/08/19 | HY-136404 | N-(2-(二乙基氨基)乙基)-5-氟-2-吡啶甲酰胺 Melanin probe-1 | 1420844-62-7 | 10mM * 1mLin DMSO | 1650元 |