AMY-101 ACETATE
| 中文名称 | AMY-101 ACETATE |
|---|---|
| 中文同义词 | |
| 英文名称 | AMY-101 acetate |
| 英文同义词 | AMY-101 acetate |
| CAS号 | |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
AMY-101 ACETATE 性质
| 形态 | 固体 |
|---|---|
| 颜色 | 白色至米白色 |
AMY-101 acetate (Cp40 acetate) 是补体 C3 的肽类抑制剂 (KD = 0.5 nM)，可抑制非人类灵长类动物自然发生的牙周炎。AMY-101 acetate (Cp40 acetate) 在 COVID-19 重症肺炎合并全身超炎症模型中具有良好的抗炎活性。
KD: 0.5 nM (C3).
AMY-101 can improve the periodontal condition of NHPs with natural chronic periodontitis.
AMY-101 can induce a long-lasting anti-inflammatory effect.
AMY-101 (4 mg/kg bodyweight, subcutaneous injection. once per 24 hr for a total of 28 days) causes a significant and long-lasting reduction in PPD, an index that measures tissue destruction.
| Animal Model: | Fifteen adult male cynomolgus monkeys (Macaca fascicularis) (7-15 years old; 5.0-7.6 kg body weight). |
| Dosage: | 0.1 mg/site; 50 μL of 2 mg/mL solution. |
| Administration: | Injected locally. (Either three times per week or once a week for 6 weeks followed by a 6-week follow-up period without treatment.) |
| Result: | Does not cause irritation in healthy gingiva. |