| Company Name: |
Shanghai Hanhong Scientific Co.,Ltd.
|
| Tel: |
021-54306202 13764082696 |
| Email: |
info@hanhongsci.com |
| Products Intro: |
Product Name:2-(N-isopropylamino)pyrimidine
CAS:4214-72-6
Purity:95+% Remarks:B62453
|
| Company Name: |
Amber MolTech LLC
|
| Tel: |
086-010-62176588 |
| Email: |
amber@jyamber.com |
| Products Intro: |
CAS:4214-72-6
Remarks:MPH-126959
|
2-Pyrimidinamine, N-(1-methylethyl)- (9CI) manufacturers
|
| | 2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Basic information |
| Product Name: | 2-Pyrimidinamine, N-(1-methylethyl)- (9CI) | | Synonyms: | isopropyl(pyrimidin-2-yl)amine;2-(N-isopropylamino)pyrimidine;N-(Isopropylamino)-2-pyrimidine;N-Isopropyl-2-pyrimidinamine;N-Isopropylpyrimidin-2-amine;2-Pyrimidinamine, N-(1-methylethyl)- (9CI);2-(Isopropylamino)pyrimidine;Isaxonine | | CAS: | 4214-72-6 | | MF: | C7H11N3 | | MW: | 137.18 | | EINECS: | | | Product Categories: | PYRIMIDINE | | Mol File: | 4214-72-6.mol |  |
| | 2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Chemical Properties |
| Melting point | 27-28℃ | | Boiling point | 229℃ | | density | 1.065 | | Fp | 93℃ | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Colourless Semi-Solid |
| | 2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Usage And Synthesis |
| Originator | Nerfactor,Ipsen,France,1981 | | Uses | Isaxonine is a neurotropic agent. Isaxonine prevents synaptic remodeling by suppression of the redundant nerve endings from additional axons. Isaxonine is transformed by cytochrome P 450 into reactive metabolites that lead to immunoallergic hepatitis in man. | | Definition | ChEBI: Isaxonine is an aminopyrimidine. | | Manufacturing Process | 6 liters of ethanol and 685 g (5 mold of 2-isopropylamino pyrimidine were
added to a 10 liter reactor and stirred. To the solution were added 600 g (5.2
mols) of phosphoric acid and the mixture was boiled under reflux for one hour.
There was obtained a dark green solution which was treated with 30 g of
carbon black. After separation and crystallization while stirring overnight, the
crystallized product was separated, washed with ethanol and dried at 50°C.
There was obtained 1,027 g (87% yield) of a white powder melting at 125°C.
The analysis of the compound showed a good correspondence with the
formula C7H14O4N3P. | | Brand name | Nerfactor;Verfactor. | | Therapeutic Function | Neurotropic | | World Health Organization (WHO) | Isaxonine phosphate was introduced in 1981 and marketed
exclusively in France for the treatment of peripheral neuropathy. In January 1983
indications for use were restricted following its association with cases of toxic
hepatitis. It was subsequently withdrawn in June 1983. |
| | 2-Pyrimidinamine, N-(1-methylethyl)- (9CI) Preparation Products And Raw materials |
|