Calusterone

Calusterone Suppliers list
Company Name: Apeloa production Co.,Limited
Tel: +8619933239880
Email: admin@apcl.com.cn
Products Intro: Product Name:calusterone
CAS:17021-26-0
Purity:0.99 Package:5KG;1KG
Company Name: Chemsky (shanghai) International Co.,Ltd  
Tel: 021-50135380
Email: shchemsky@sina.com
Products Intro: Product Name:Calusterone;(7β,17β)-17-Hydroxy-7,17-diMethylandrost-4-en-3-one; 7β,17-DiMethyltestosterone; 17β-Hydroxy-7β,17-diMethylandrost-4-en-3-one; 7β,17α-DiMethyltestosterone; Methosarb; NSC 88536; U 22550;
CAS:17021-26-0
Purity:98+% Package:1Mg;5Mg;10Mg;50Mg;100Mg;500Mg
Company Name: Shanghai Saikerui Biotechnology Co. , Ltd.  
Tel: 021-58000709 15900491054
Email: info@scrbio.com
Products Intro: Product Name:4-ANDROSTEN-7β, 17α-DIMETHYL-17β-OL-3-ONE
CAS:17021-26-0
Purity:98+ Package:1mg;5mg;10mg
Company Name: Shanghai Hao Zhun Biological Technology Co., Ltd.  
Tel: 15800340161
Email: info@zzsrm.com
Products Intro: Product Name:Calusterone
CAS:17021-26-0
Company Name: Toronto Research Chemicals  
Tel: +1 (416) 665-9696
Email: info@trc-canada.com
Products Intro: CAS:17021-26-0
Package:150USD/5mg;1200USD/50mg
Calusterone Basic information
Product Name:Calusterone
Synonyms:(7S,8R,9S,10R,13S,14S,17S)-17-hydroxy-7,10,13,17-tetramethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-3-one;7β,17α-Dimethyl-17β-hydroxyandrost-4-en-3-one;Methosarb;NSC-88536;U-22,550;U-22550;Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7β,17β)-;4-ANDROSTEN-7β, 17α-DIMETHYL-17β-OL-3-ONE
CAS:17021-26-0
MF:C21H32O2
MW:316.48
EINECS:
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:17021-26-0.mol
Calusterone Structure
Calusterone Chemical Properties
Melting point 127-129°
alpha D +57° (CHCl3)
Boiling point 463.29°C (rough estimate)
density 0.9575 (rough estimate)
refractive index 1.5100 (estimate)
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka15.13±0.70(Predicted)
color White to Off-White
Safety Information
Hazardous Substances Data17021-26-0(Hazardous Substances Data)
MSDS Information
Calusterone Usage And Synthesis
OriginatorMethosarb,Upjohn,US,1973
UsesSynthetic androgen epimeric with Bolasterone (B674970). Has been used in treatment of breast cancer. Controlled substance (anabolic steroid).
DefinitionChEBI: Calusterone is a 3-hydroxy steroid. It has a role as an androgen.
Manufacturing ProcessAs described in US Patent 3,029,263, one possibility is a multistep synthesis starting from 3β,17β-dihydroxy-17α-methyl-5-androstene.
Alternatively, as described in US Patent 3,341,557, 6-dehydro-17- methyltestosterone may be used as the starting material. A mixture of 0.4 g of cuprous chloride, 20 ml of 4M methylmagnesium bromide in ether and 60 ml of redistilled tetrahydrofuran was stirred and cooled in an ice bath during the addition of a mixture of 2.0 g of 6-dehydro-17-methyltestosterone, 60 ml of redistilled tetrahydrofuran and 0.2 g of cuprous chloride. The ice bath was removed and stirring was continued for four hours. Ice and water were then carefully added, the solution acidified with 3 N hydrochloric acid and extracted several times with ether. The combined ether extracts were washed with a brine-sodium carbonate solution, brine and then dried over anhydrous magnesium sulfate, filtered and then poured over a 75-g column of magnesium silicate (Florisil) packed wet with hexanes (Skellysolve B). The column was eluted with 250 ml of hexanes, 0.5 liter of 2% acetone, two liters of 4% acetone and 3.5 liters of 6% acetone in hexanes.
Four 250-ml fractions were collected followed by 150 ml fractions. The residues from fractions 8 to 16 were combined and rechromatographed over a 125-g column of magnesium silicate. The solumn was eluted with 6% acetone in hexanes which was collected in 150 ml portions. Fractions 18 to 29 were combined and dissolved in acetone, decolorized with charcoal, and recrystallized from acetone. One gram of a crystalline mixture of the 7epimers of 7,17-dimethyltestosterone was obtained melting at 120° to 140°C.
Therapeutic FunctionAntineoplastic
Calusterone Preparation Products And Raw materials
Raw materials4,6-ANDROSTADIEN-17-ALPHA-METHYL-17-BETA-OL-3-ONE-->Methylmagnesium Bromide
Tag:Calusterone(17021-26-0) Related Product Information
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