Ciramadol

Ciramadol Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Products Intro: Product Name:Ciramadol
CAS:63269-31-8
Package:25mg;1520USD|50mg;1980USD|100mg;2500USD
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Products Intro: Product Name:Ciramadol
CAS:63269-31-8
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
Company Name: CLEARSYNTH LABS LTD.  
Tel: +91-22-45045900
Email: sales@clearsynth.com
Products Intro: Product Name:Ciramadol
CAS:63269-31-8
Company Name: United States Biological  
Tel: 800.520.3011 or 781.639.5092
Email: chemicals@usbio.net
Products Intro: Product Name:Ciramadol
CAS:63269-31-8
Company Name: Lanospharma Laboratories Co.,Ltd  
Tel: 13440048448
Email: sales@lanospharma.com
Products Intro:

Ciramadol manufacturers

  • Ciramadol
  • Ciramadol pictures
  • $1520.00 / 25mg
  • 2024-11-19
  • CAS:63269-31-8
  • Min. Order:
  • Purity:
  • Supply Ability: 10g
Ciramadol Basic information
Product Name:Ciramadol
Synonyms:3-[(R)-(Dimethylamino)[(1R)-2α-hydroxycyclohexan-1α-yl]methyl]phenol;WY-15705;Ciramadolum;Ciramadolum [inn-latin];Phenol, 3-((R)-(dimethylamino)((1R,2R)-2-hydroxycyclohexyl)methyl)-;Unii-9nq109ow0g;Ciramadol
CAS:63269-31-8
MF:C15H23NO2
MW:249.35
EINECS:
Product Categories:
Mol File:63269-31-8.mol
Ciramadol Structure
Ciramadol Chemical Properties
Melting point 191-193°
alpha D25 -46.92° (c = 1.061 in methanol)
Boiling point 385.7±17.0 °C(Predicted)
density 1.127±0.06 g/cm3(Predicted)
pka9.84±0.10(Predicted)
Safety Information
MSDS Information
Ciramadol Usage And Synthesis
OriginatorCiramadol,American Home
UsesCiramadol is an opioid analgesic. It is a mixed agonist-antagonist for the μ-opioid receptor with relatively low abuse potential and a ceiling on respiratory depression.
DefinitionChEBI: Ciramadol is a member of cyclohexanols.
Manufacturing Processm-Methoxymethoxybenzaldehyde (167 g, 1.0 mole) and cyclohexanone (318 ml, 3.0 moles) were refluxed for 4 hours under nitrogen with a solution of potassium hydroxide (50 g, 0.89 moles) in water (1 liter). After cooling the oily layer was extracted with ether (twice). The ether solution was washed with water (thrice), brine, dried (sodium sulfate), and evaporated. The residue was distilled and the product obtained as a yellow oil (132 g.), boiling point of m-methoxymethoxybenzalcyclohexanone 173-176°C at 0.3 mm, λmax 287 nm (ethanol, ε 13,000).
A solution of m-methoxybenzalcyclohexanone (50 g ) in ether (50 ml) was cooled to -5°C in a pressure bottle and treated with 20 ml dimethylamine. The bottle was stoppered and left at room temperature during 60 hours. The above reaction was performed in duplicate (IR monitoring indicates the mixture attains an equilibrium concentration in which the β-dimethylamino ketone addition product is favored over the m-methoxybenzalcyclohexanone by a ratio of ca. 2:1). the combined total reaction mixtures were added dropwise under nitrogen to a stirred suspension of LiAlH4 (20 g)
in ether (1.2 liters) and the mixture was refluxed during 4 hours. The ice cooled reaction mixture was treated with 3% aqueous sodium hydroxide solution (100 ml) and filtered. The precipitated solids were washed with boiling ether and the combined filtrates evaporated to approximately 1 liter. The ether layer was extracted (twice) with an excess of dilute hydrochloric acid followed by a water extraction. The combined aqueous extracts were back extracted with ether, basified with 50% sodium hydroxide solution and extracted with ether (twice). The ether layers were washed with brine and evaporated to an oil (50 g) to give a mixture containing predominantly (96%) of two components. 32 g of the residue were chromatographed on a Woelm alumina column (900 g
Therapeutic FunctionAnalgesic
Ciramadol Preparation Products And Raw materials
Raw materialsCyclohexanone-->Hydrochloric acid-->Hydroxide
Tag:Ciramadol(63269-31-8) Related Product Information
Ciramadol