茚托利辛
中文名称 | 茚托利辛 |
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中文同义词 | 茚托利辛;化合物 T15586;11-((3-(二甲氨基)丙基)氨基)-8-甲基-7H-苯并[E]吡啶并[4,3-B]吲哚-3-醇 |
英文名称 | Intoplicine |
英文同义词 | Intoplicine;11-(3-Dimethylaminopropylamino)-3-hydroxy-8-methyl-7H-benzo[e]pyrido[4,3-b]indole;7H-Benzo[e]pyrido[4,3-b]indol-3-ol, 11-[[3-(dimethylamino)propyl]amino]-8-methyl- |
CAS号 | 125974-72-3 |
分子式 | C21H24N4O |
分子量 | 348.44 |
EINECS号 | |
相关类别 | |
Mol文件 | 125974-72-3.mol |
结构式 |
茚托利辛 性质
熔点 | 216-218 °C |
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沸点 | 635.5±55.0 °C(Predicted) |
密度 | 1.286±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
酸度系数(pKa) | 8.26±0.30(Predicted) |
颜色 | 白色至米白色 |
Topoisomerase I
|
Topoisomerase II
|
Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-101647 | Intoplicine | 1 mg | 3200元 | |
2024/08/19 | HY-101647 | 茚托利辛 Intoplicine | 125974-72-3 | 5mg | 8000元 |