木聚硫钠
| 中文名称 | 木聚硫钠 |
|---|---|
| 中文同义词 | 化合物 T12420L;戊聚糖多硫酸酯钠 |
| 英文名称 | Pentosan |
| 英文同义词 | 4-o-Methyl-alpha-D-glucurono-beta-D-xylan, hydrogen sulfate, sodium salt;beta-D-Xylan, (1-4), 2,3-bis(hydrogen sulfate), sodium salt;Cartrophen;Cb 8061;Hemoclar;Hemoclar [french];Pentosan Polysulfate Sodium (W/W 43%) |
| CAS号 | 140207-93-8 |
| 分子式 | |
| 分子量 | 0 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | Mol File |
| 结构式 |
木聚硫钠 性质
| 储存条件 | 4°C, sealed storage, away from moisture |
|---|---|
| 形态 | 固体 |
| 颜色 | 白色至米白色 |
|
HIV-1
|
Pentosan Polysulfate Sodium has been shown to inhibit HIV-1 activity with an ED
50
of 0.19 μg/mL in MT-4 cells. It inhibits HIV-1 antigen expression in HUT-78 cells at an ED
50
of 0.02 μg/mL, and complete inhibition of HIV-1 antigen expression is obtained at a concentration of 4.0 μg/mL.
Pentosan Polysulfate Sodium suppresses NF-κB, decreases the proinflammatory actions of TNFα, and decreases high glucose and advanced glycation end products (AGEs) stimulated MCP-1 production.
Pentosan Polysulfate Sodium has been shown to decreases interstitial inflammation and glomerulosclerosis in 5/6 nephrectomized rats. Pentosan polysulfate treatment preserves renal function, significantly reduces albuminuria, and markedly decreases the severity of renal lesions, including tubulointerstitial inflammation. Pentosan Polysulfate Sodium also reduces upregulation of TNFα and proinflammatory genes in aging diabetic kidneys.