8-O-乙酰山栀苷甲酯
中文名称 | 8-O-乙酰山栀苷甲酯 |
---|---|
中文同义词 | 8-O-ACETYL SHANZHISIDE METHYL ESTER 8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯(标准品);8-O-乙酰山栀苷甲酯;8-O-乙酰山栀苷甲酯, >98%;8-O-乙酰山栀苷甲酯, 来源于独一味;8-O-乙酰山栀苷甲酯(对照品) |
英文名称 | 8-O-acetyl shanzhiside methyl ester |
英文同义词 | (1S)-1α-(β-D-Glucopyranosyloxy)-5α-hydroxy-7α-acetoxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;1α-(β-D-Glucopyranosyloxy)-7α-acetoxy-5α-hydroxy-7-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid methyl ester;7α-Acetoxy-1α-(β-D-glucopyranosyloxy)-1,4aα,5,6,7,7aα-hexahydro-5α-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid methyl ester;Barlerin;O-Acetyl Shanzhiside Methyl Ester, 8-;8-Acetylshanzhiside Methyl ester;UMbroside;8-O-Acetyl shanzhiside methyl ester, 98%, from Lamiophlomis rotata (Benth. ex Hook.f.) Kud |
CAS号 | 57420-46-9 |
分子式 | C19H28O12 |
分子量 | 448.42 |
EINECS号 | |
相关类别 | 中药对照品;标准品;植物提取物;对照品;植提标准品;分析试剂标准品;chemical reagent;pharmaceutical intermediate;phytochemical;标准品-对照品;标准品-中药标准品;标准品 -中药标准品;环烯醚萜;标准品,对照品;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract |
Mol文件 | 57420-46-9.mol |
结构式 | ![]() |
8-O-乙酰山栀苷甲酯 性质
沸点 | 634.2±55.0 °C(Predicted) |
---|---|
密度 | 1.52 |
溶解度 | 溶于甲烷 |
形态 | 粉末 |
酸度系数(pKa) | 12.80±0.70(Predicted) |
颜色 | 白色 |
Target | Value |
NF-κB
() |
Treatment of SH-SY5Y cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) blocks TNF-α-induced nuclear transcription factor κB (NF-κB) activation and decreases high-mobility group box-1 (HMGB-1) expression. . Treatment of H9c2 cells with Barlerin (8-O-Acetyl shanzhiside methyl ester) 9 μM blocks TNF-α-induced NF-κB phosphorylation by blocking High-mobility group box1 (HMGB1) expression.
Barlerin (8-O-Acetyl shanzhiside methyl ester) 40 mg/kg demonstrates significant neuroprotective effect even after delayed administration at 4 hr after I/R. Barlerin 40 mg/kg attenuates the histopathological damage, decreases brain swelling, inhibits NF-κB activation and reduces HMGB-1 expression in ischaemic brain tissue. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly promotes angiogenesis in the ischaemic brain and improves functional outcome after stroke. Barlerin also significantly increases vascularization compared with vehicle treatment. It increases the expression of VEGF, Ang1, phosphorylation of Tie2 and Akt VEGF. Barlerin (8-O-Acetyl shanzhiside methyl ester) significantly shortens capillary blood clotting time and reduces blood loss volume, but does not influence mice activated partial thromboplastin time, prothrombin time or thrombin time. It significantly prolongs euglobulin clot lysis time in hyperfibrinolysis mice.
药理药效:有活化淤血、 止痛止血。
安全信息
安全说明 | 24/25 |
---|---|
海关编码 | 29389090 |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-N0758 | Barlerin | 1 mg | 365元 | |
2024/04/30 | HY-N0758 | 8-O-乙酰山栀苷甲酯 Barlerin | 57420-46-9 | 5mg | 800元 |