GW501516
| 中文名称 | GW501516 |
|---|---|
| 中文同义词 | 2-(2-甲基-4-(((4-甲基-2-(4-(三氟甲基)苯基)噻唑-5-基)甲基)硫基)苯氧基)乙酸;2-(4-((2-(4-(三氟甲基)苯基)-5-甲基噻唑-4-基)甲基硫基)-2-甲基苯氧基)乙酸;2-(4-((2-(4-(三氟甲基)苯基)-5-甲基噻唑-4-基)甲基硫基)-2-甲基苯氧基)乙酸 GW-501516;2-(2-甲基-4-(((4-甲基-2-(4-(三氟甲基)苯基)噻唑-5-基)甲基)硫代)苯氧基)乙酸;2-(4-((2..苯氧基)乙酸;317318-70-02-(4-((2-(4-(三氟甲基)苯基)-5-甲基噻唑-4-基)甲基硫基)-2-甲基苯氧基)乙酸;化合物GW501516;2-(4-((2-(4-(三氟甲基)苯基)-5-甲 |
| 英文名称 | GW-501516 |
| 英文同义词 | 2-[2-methyl-4-[[4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl]methylsulfanyl]phenoxy]acetic acid;GW 501516, >=98%;ENDUROBOL (GW-501516)/CARDARINE/;Cardarine(GW501516, GSK-516);GW-501615;2-(4-((2-(4-(Trifluoromethyl)phenyl)-4-methylthiazol-5-yl)methylthio)-2-methylphenoxy)acetic a;{2-Methyl-4-[4-Methyl-2-(4-trifluoroMethyl-phenyl)-thiazol-5-ylMethylsulfanyl]-phenoxy}-acetic acid;Aceticacid, [2-Methyl-4-[[[4-Methyl-2-[4-(trifluoroMethyl)phenyl]-5-thiazolyl]Methyl]thio]phenoxy]-(9CI) |
| CAS号 | 317318-70-0 |
| 分子式 | C21H18F3NO3S2 |
| 分子量 | 453.5 |
| EINECS号 | 1592732-453-0 |
| 相关类别 | 信号转导通路激酶抑制剂;原料药;化学试剂、精细化学品、医药中间体;医药原料;原料药【仅供科研】;代谢;保健品添加剂;小分子抑制剂，天然产物;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;kl;Inhibitor;Antineoplastic;SARMs(Selective androgen receptor modulator);Inhibitors;化合物;Sarms;库存;出口SARM系列;化学产品;化工中间体;化学试剂 |
| Mol文件 | 317318-70-0.mol |
| 结构式 |  |
GW501516 性质
| 熔点 | 134-136°C |
|---|---|
| 沸点 | 584.5±60.0 °C(Predicted) |
| 密度 | 1.42±0.1 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | 在DMSO中的溶解度为20mg/mL，澄清 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 3.17±0.10(Predicted) |
| 颜色 | 白色至米色 |
| BRN | 18515150 |
| 稳定性 | 感光 |
| InChI | InChI=1S/C21H18F3NO3S2/c1-12-9-16(7-8-17(12)28-10-19(26)27)29-11-18-13(2)25-20(30-18)14-3-5-15(6-4-14)21(22,23)24/h3-9H,10-11H2,1-2H3,(H,26,27) |
| InChIKey | YDBLKRPLXZNVNB-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC=C(SCC2SC(C3=CC=C(C(F)(F)F)C=C3)=NC=2C)C=C1C |
| CAS 数据库 | 317318-70-0 |
| Target | Value |
|
PPARδ
(Cell-free assay) | 1 nM(Ki) |
GW 501516 is shown to be the most potent and selective PPARα agonists known with an EC 50 of 1.1 nM against PPARα and 1000-fold selectivity over the other human subtypes, PPARα and-γ. GW 501516 exerts anti-inflammatory effects in mouse cultured proximal tubular (mProx) cells. GW 501516 inhibits palmitate- and TNFα-induced increases in MCP-1 mRNA expression in a dose-dependent manner.
GW 501516 causes impaired bone formation, leading to decreased BMD and deterioration of bone properties in OVX rats. GW 501516 attenuates interstitial inflammation and proximal tubular cell damage in a protein-overload mouse nephropathy model. GW 501516 treatment enhances running endurance and the proportion of succinate dehydrogenase (SDH)-positive muscle fibres in both trained and untrained mice.
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | AI9105500 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | S1473 | GW501516 GW501516 | 317318-70-0 | 5mg | 2205.27元 |
| 2024/11/08 | S1473 | GW501516 GW501516 | 317318-70-0 | 25mg | 7945.88元 |