BMS309403
中文名称 | BMS309403 |
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中文同义词 | 2-[[2'-(5-乙基-3,4-二苯基-1H-吡唑-1-基)[1,1'-联苯]-3-基]氧基]乙酸;2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸;2'-(5-乙基-3,4-二苯基-吡唑-1-基)-双苯基-3-氧基]乙酸;化合物BMS-309403;INHIBITOR|||BMS309403|||SELECTIVE|||BMS 309403|||BMS-309403|||ORAL|||FATTY ACID-BINDING PROTEIN|||INHIBIT|||BMS-309403|||BMS 309403|||ENDOTHELIAL|||UPTAKE|||GLUCOSE|||FABP|||BMS309403|||FUNCTION |
英文名称 | 2''-(5-ETHYL-3,4-DIPHENYL-PYRAZOL-1-YL)-BIPHENYL-3-YLOXY]ACETIC ACID |
英文同义词 | 2''-(5-ETHYL-3,4-DIPHENYL-PYRAZOL-1-YL)-BIPHENYL-3-YLOXY]ACETIC ACID;2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]- acetic acid;BMS309403;3-[2-(5-ETHYL-3,4-DIPHENYLPYRAZOL-1-YL)PHENYL]PHENOXYACETIC ACID;CS-495;BMS 309403;BMS309403;Acetic acid, 2-[[2'-(5-ethyl-3,4-diphenyl-1H-pyrazol-1-yl)[1,1'-biphenyl]-3-yl]oxy]-;2-[3-[2-(5-ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid |
CAS号 | 300657-03-8 |
分子式 | C31H26N2O3 |
分子量 | 474.55 |
EINECS号 | |
相关类别 | 试剂;FABP4 Inhibitor;selective inhibitor of adipocyte Fatty-Acid-Binding Protein (aFABP/aP2) |
Mol文件 | 300657-03-8.mol |
结构式 |
BMS309403 性质
沸点 | 657.5±55.0 °C(Predicted) |
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密度 | 1.17 |
储存条件 | Sealed in dry,Room Temperature |
溶解度 | 可溶于 DMSO(高达至少 25 mg/ml)。 |
形态 | 白色粉末状固体。 |
酸度系数(pKa) | 3.15±0.10(Predicted) |
颜色 | 灰白色或浅黄色 |
稳定性 | 可在-20°下的DMSO中的溶液储存长达1个月。 |
BMS309403是FABP4小分子抑制剂,Kd值为4 nM,对FABP4的选择性比对FABP5和FABP3高100倍以上。
Target | Value |
FABP4
(Cell-free assay) | 4 nM(Kd) |
Treatment with BMS-309403 significantly decreased MCP-1 production from THP-1 macrophages in a dose- and time-dependent manner.
BMS-309403 sodium (15 mg/kg; chronic treatment; daily for 6 weeks) improves endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but did not affect endothelium-independent relaxations.
Animal Model: | C57BL/6J mice (ApoE −/− mice) |
Dosage: | 15 mg/kg |
Administration: | Chronic treatment ; daily for 6 weeks |
Result: | Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE −/− mice. |
安全信息
海关编码 | 2933199090 |
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-101903 | BMS309403 BMS-309403 | 300657-03-8 | 5mg | 700元 |
2024/04/30 | S6622 | BMS309403 BMS309403 | 300657-03-8 | 5mg | 794.93元 |