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2-Methyl-4H-3,1-benzoxazin-4-one

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Products Intro: Product Name:2-methyl-3,1-benzoxazin-4-one
CAS:525-76-8
Purity:98% Package:25kg;0.00;USD|100kg;0.00;USD Remarks:95%
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Products Intro: Product Name:2-Methyl-4H-3,1-benzoxazin-4-one
CAS:525-76-8
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Products Intro: Product Name:2-Methyl-4H-3,1-benzoxazin-4-one
CAS:525-76-8
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CAS:525-76-8
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Products Intro: Product Name:2-METHYL-3,1-BENZOXAZA-4-ONE
CAS:525-76-8
Purity:99% Package:100g ;1KG ;5KG 25KG

2-Methyl-4H-3,1-benzoxazin-4-one manufacturers

2-Methyl-4H-3,1-benzoxazin-4-one Basic information
Product Name:2-Methyl-4H-3,1-benzoxazin-4-one
Synonyms:TIMTEC-BB SBB000135;2-methyl-4h-1-benzoxazin-4-one;2-METHYL-3,1-BENZOXAZA-4-ONE;2-METHYL-4H-3,1-BENZOXAZIN-4-ONE;ACETYL ANTHRANIL;ACETANTHRANIL;2-2-METHYL-4H-3,1-BENZOXAZIN-4-ONE;4H-3,1-benzoxazin-4-one, 2-methyl-
CAS:525-76-8
MF:C9H7NO2
MW:161.16
EINECS:208-381-7
Product Categories:API intermediates;Benzoxazines;Building Blocks;Heterocyclic Building Blocks
Mol File:525-76-8.mol
2-Methyl-4H-3,1-benzoxazin-4-one Structure
2-Methyl-4H-3,1-benzoxazin-4-one Chemical Properties
Melting point 79-82 °C(lit.)
Boiling point 144-145 °C(Press: 12 Torr)
density 1.25±0.1 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka2.84±0.20(Predicted)
InChIInChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
InChIKeyWMQSKECCMQRJRX-UHFFFAOYSA-N
SMILESN1C2=CC=CC=C2C(=O)OC=1C
EPA Substance Registry System4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
HazardClass IRRITANT
MSDS Information
ProviderLanguage
SigmaAldrich English
2-Methyl-4H-3,1-benzoxazin-4-one Usage And Synthesis
Uses2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.
Synthesis Reference(s)The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038
SynthesisIn 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-METHYL-3,1-BENZOXAZA-4-ONE
Tag:2-Methyl-4H-3,1-benzoxazin-4-one(525-76-8) Related Product Information
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