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| | BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT Basic information |
| Product Name: | BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT | | Synonyms: | BZ-VAL-GLY-ARG-AMC TFA SALT;BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT;Bz-VGR-AMC;Bz-Val-Gly-Arg-AMC;N-[(2S)-1-[[2-[[(2S)-5-(diaminomethylideneamino)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-3-methyl-1-oxobutan-2-yl]benzamide;L-Argininamide, N-benzoyl-L-valylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-;N-Benzoyl-L-valylglycyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-L-argininamide;Bz-Val-Gly-Arg-AMC (I-1085.0050) | | CAS: | 87779-49-5 | | MF: | C30H37N7O6 | | MW: | 591.66 | | EINECS: | | | Product Categories: | Miscellaneous Enzyme | | Mol File: | 87779-49-5.mol |  |
| | BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT Chemical Properties |
| storage temp. | -15°C | | solubility | Soluble in DMSO. | | form | White powder. | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT Usage And Synthesis |
| Description | Bz-VGR-AMC (87779-49-5) may be used for measuring the trypsin-like activity of the 20S proteasome, in combination with Suc-LLVY-AMC (Cat.# 10-2971, for assaying its chymotrypsin-like activity) and Z-LLE-AMC, (for determining its PGPH activity). Fluorogenic substrate. Ex.: 380nm Em.: 460nm. | | Uses | Bz-Val-Gly-Arg-AMC is a bioactive compound used in assaying the degree of inhibition conferred by PS-341, a potent peptidylboronic acid with anticancer properties. | | References | 1) Gillardon?et al. (2007),?The 20S proteasome isolated from Alzheimer’s disease brain shows post-translational modifications but unchanged proteolytic activity; J. Neurochem.,?101?1483
2) Kim?et al. (2002),?Navigation inside a protease: substrate selection and product exit in tricorn protease from Thermoplasma acidophilum; J. Mol. Biol.,?324?1041
3) Dahlmann?et al. (2000),?Different proteasome subtypes in a single tissue exhibit different enzymatic properties; J. Mol. Biol.,?303?643
4) Lightcap?et al. (2000),?Proteasome inhibition measurements: clinical application; Clin. Chem.,?46?673 |
| | BZ-VAL-GLY-ARG-AMC TRIFLUOROACETATE SALT Preparation Products And Raw materials |
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