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| | AC-5216 Basic information |
| Product Name: | AC-5216 | | Synonyms: | EMapunil;XBD-173;N-Benzyl-N-ethyl-2-(7-Methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetaMide;9H-Purine-9-acetaMide,N-ethyl-7,8-dihydro-7-Methyl-8-oxo-2-phenyl-N-(phenylMethyl)-;AC 5216 (Emapunil);N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide;Emapunil(AC-5216);AC-5216 | | CAS: | 226954-04-7 | | MF: | C23H23N5O2 | | MW: | 401.46 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 226954-04-7.mol |  |
| | AC-5216 Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMF: 30 mg/mL; DMF:PBS (pH 7.2) (1:20): 0.05 mg/mL; DMSO: 5 mg/mL | | form | powder | | color | white to beige |
| | AC-5216 Usage And Synthesis |
| Uses | Emapunil possesses anxiolytic and antidepressant-like effects and a ligand for translocator protein (TSPO), which plays an important role in the depression treatment. | | Biochem/physiol Actions | XBD173 (emapunil, AC-5216) is a potent and selective translocator protein 18 kDa (TSPO) ligand with a Ki value of 0.297 nM. XBD173 acts at the TSPO translocator protein, formerly called the peripheral benzodiazepine receptor, which is involved in production of neuroactive steroids such as allopregnanolone in the brain. TSPO carries cholesterol from the outer to the inner mitochondrial membrane, which is the rate-limiting step of steroidogenesis. XBD173 enhances GABA-mediated neurotransmission via induction of neurosteroidogenesis and exhibits anti-anxiety and antidepressant-like effects. | | storage | Store at +4°C |
| | AC-5216 Preparation Products And Raw materials |
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