硫代乙基氨基乙基胺盐酸盐
中文名称 | 硫代乙基氨基乙基胺盐酸盐 |
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中文同义词 | 氨磷汀硫醇;硫代乙基氨基乙基胺盐酸盐;2-[(3-氨基丙基)氨基]乙硫醇二盐酸盐;氨磷汀硫醇 USP标准品;氨磷汀杂质11;2-((3-氨基丙基)氨基)乙硫醇二盐酸;硫代乙基氨基乙基胺盐酸盐 AMIFOSTINE THIOL (WR-1065) DIHYDROCHLORIDE;氨磷汀杂质2 二盐酸盐 |
英文名称 | Amifostine Thiol Dihydrochloride |
英文同义词 | Amifostine Thiol Dihydrochloride;2-[(3-Aminopropyl)amino]ethanethioldihydrochloride;Amifostine Thiol (50 mg) (2-[(3-aminopropyl)amino]ethanethiol, dihydrochloride);AMifostine Thiol;2-[(3-AMinopropyl)aMino]ethanethiol Hydrochloride;WR-1065 dihydrochloride;WR-1065 2HCl;Amifostine Thiol Dihydrochloride (90%) |
CAS号 | 14653-77-1 |
分子式 | C5H14N2S |
分子量 | 134.24306 |
EINECS号 | |
相关类别 | 合成;杂质对照品;化学试剂;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds |
Mol文件 | 14653-77-1.mol |
结构式 | ![]() |
硫代乙基氨基乙基胺盐酸盐 性质
熔点 | 184-186°C |
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储存条件 | -20°C |
溶解度 | H2O:≥20mg/mL |
形态 | 粉末 |
颜色 | 白色至类白色 |
稳定性 | 吸湿性 |
p53
The DNA-binding activity is increased in a WR-1065 dihydrochloride (WR-1065) concentration-dependent manner. Cells treated with 1 mM WR-1065 dihydrochloride for 24 h reveal that all of the p53-induced genes analyzed are transactivated following WR-1065 dihydrochloride treatment, in a p53-dependent manner. Significantly, treatment with WR-1065 dihydrochloride leads to a 3-fold increase in luciferase expression driven by AP-1, and a 5-fold increase when this reporter gene is driven by NF-κB, when these values are normalized to the level of the cotransfected β-galactosidase gene.
The results show that wR-1065 dihydrochloride (WR-1065) attenuates the severity of 6-OHDA-induced catalepsy (P<0.001) when compare with 6-OHDA-lesioned rats. Also it has been observed that WR-1065 dihydrochloride improves catalepsy in dose dependent manner (P<0.001). Pretreatment with three different doses of WR-1065 dihydrochloride (20, 40 and 80 μg/2 μL/rat) for 3 days before 6-OHDA administration, significantly (P<0.001) elevates SOD activity and restores it to normal range compare with 6-OHDA lesioned rats.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-137864 | Amifostine thiol | 5 mg | 562元 | |
2024/04/30 | HY-137864 | 硫代乙基氨基乙基胺盐酸盐 Amifostine thiol | 14653-77-1 | 10mg | 900元 |