CS-1226
| 中文名称 | CS-1226 |
|---|---|
| 中文同义词 | MDMX小分子抑制剂(SJ-172550);化合物SJ-172550;2-(2-氯-6-乙氧基-4-((3-甲基-5-氧代-1-苯基-1H-吡唑-4(5H)-亚基)甲基)苯氧基)乙酸甲酯 |
| 英文名称 | 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester |
| 英文同义词 | 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]aceticacidmethylester;SJ 172550;MDMX Antagonist, SJ-172550;CS-1226;MDMX Antagonist, SJ-172550 - CAS 431979-47-4 - Calbiochem;Acetic acid, 2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-, methyl ester;Methyl 2-(2-chloro-6-ethoxy-4-((3-methyl-5-oxo-1-phenyl-1H-pyrazol-4(5H)-ylidene)methyl)phenoxy)acetate;E3 ligating enzyme,Ubiquitin activating enzyme,E2 conjugating enzyme,E1/E2/E3 Enzyme,MDM-2/p53,Ubiquitin ligase,SJ172550,E1 activating enzyme,SJ 172550,SJ-172550,inhibit,Ubiquitin conjugating enzyme,Inhibitor |
| CAS号 | 431979-47-4 |
| 分子式 | C22H21ClN2O5 |
| 分子量 | 428.87 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 431979-47-4.mol |
| 结构式 |  |
CS-1226 性质
| 沸点 | 560.8±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.27±0.1 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亚砜：≥30mg/mL |
| 酸度系数(pKa) | -0.30±0.40(Predicted) |
| 形态 | 粉末 |
| 颜色 | 橙色 |
SJ-172550是MDMX的小分子抑制剂; 与野生型p53肽竞争性结合于MDMX的EC50值为5 μM。
IC50: 5 μM (MDMX)
The p53 pathway is disrupted in virtually every human tumor. SJ-172550 binds the p53-binding pocket of MDMX, thereby displacing p53. SJ-172550 binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified. The effect of SJ-172550 is additive when combined with an MDM2 inhibitor nutlin-3a. SJ-172550 acts through a complicated mechanism in which the compound forms a covalent but reversible complex with MDMX and locks MDMX into a conformation that is unable to bind p53. The relative stability of this complex is influenced by many factors including the reducing potential of the media, the presence of aggregates.
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-16664 | SJ-172550 | 1 mg | 360元 | |
| 2024/04/30 | HY-16664 | CS-1226 SJ-172550 | 431979-47-4 | 5mg | 675元 |