TZP 101
中文名称 | TZP 101 |
---|---|
中文同义词 | 化合物 T17202;化合物 ULIMORELIN |
英文名称 | TZP 101 |
英文同义词 | TZP 101;UliMorelin;(7R,10R,13S,16R)-13-cyclopropyl-7-[(4-fluorophenyl)methyl]-10,11,16-trimethyl-17-oxa-5,8,11,14-tetrazabicyclo[16.4.0]docosa-1(22),18,20-triene-6,9,12-trione |
CAS号 | 842131-33-3 |
分子式 | C30H39FN4O4 |
分子量 | 538.6534632 |
EINECS号 | |
相关类别 | |
Mol文件 | 842131-33-3.mol |
结构式 |
TZP 101 性质
Ulimorelin (TZP-101; 0.3-5 mg/kg; i.v.) causes a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum.
Ulimorelin (1, 3, 5 mg/kg; i.v.) causes a substantial and prolonged (~1 h) increase in colorectal propulsive activity and expulsion of colonic contents.
Ulimorelin (p.o.; 8 mg/kg) has a C
max
of 0.39 μM and a AUC of 82 μM•min for rats. Ulimorelin (i.v.; 2 mg/kg) has a T
1/2
of 50 mins, a CL of 24 mL/min/kg, and a V
ss
of 1.7 L/kg for rats.
Animal Model: | Male Sprague-Dawley rats |
Dosage: | 0.3, 1, 3, 5 mg/kg |
Administration: | i.v. |
Result: | Caused a dose dependent increase in the numbers and amplitudes of phasic pressure waves recorded from the colorectum. |