ISTAROXIME 盐酸盐
| 中文名称 | ISTAROXIME 盐酸盐 |
|---|---|
| 中文同义词 | ISTAROXIME 盐酸盐;NA+,K+-ATPASE抑制剂(ISTAROXIME HYDROCHLORIDE);化合物 T15599;伊司他肟盐酸 |
| 英文名称 | PST2744 (hydrochloride) |
| 英文同义词 | IstaroxiMe (hydrochloride);PST 2744 (hydrochloride);PST2744 (hydrochloride);PST-2744 (hydrochloride);(5alpha)-Androstane-3,6,17-trione 3-[O-(2-aminoethyl)oxime] monohydrochloride;Istaroxime hydrochloride, >=98%;Istaroxime hydrochloride(PST2744);PST2774;PST-2774 |
| CAS号 | 374559-48-5 |
| 分子式 | C21H33ClN2O3 |
| 分子量 | 396.96 |
| EINECS号 | |
| 相关类别 | 细胞生物学试剂 |
| Mol文件 | 374559-48-5.mol |
| 结构式 |  |
ISTAROXIME 盐酸盐 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 粉末 |
| 颜色 | 白色至浅棕色 |
IC50: 0.11 μM (Na + ,K + -ATPase)
Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na + ,K + -ATPase. Istaroxime (PST2744) inhibits the Na + /K + -ATPase activity from dog kidney with an IC 50 value of 0.43 ± 0.15 μM. Inhibition of Na + /K + -ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744.
Istaroxime (PST2744) induces a progressive increase in +dP/dt max throughout the infusion that reaches 80% (ED 80 ) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (ED max ) of 4.88±0.6 mg/kg.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-15718A | ISTAROXIME 盐酸盐 Istaroxime hydrochloride | 374559-48-5 | 2mg | 950元 |
| 2024/11/08 | HY-15718A | ISTAROXIME 盐酸盐 Istaroxime hydrochloride | 374559-48-5 | 5mg | 1800元 |