(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇
| 中文名称 | (3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇 |
|---|---|
| 中文同义词 | (3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇;化合物 T13551 |
| 英文名称 | Araliadiol |
| 英文同义词 | Araliadiol;(3S,8R,9Z)-1,9-Pentadecadiene-4,6-diyne-3,8-diol;1,9-Pentadecadiene-4,6-diyne-3,8-diol, (3S,8R,9Z)- |
| CAS号 | 1354638-93-9 |
| 分子式 | C15H20O2 |
| 分子量 | 232.3181 |
| EINECS号 | |
| 相关类别 | 其它天然产物 |
| Mol文件 | 1354638-93-9.mol |
| 结构式 |  |
(3S,8R,9Z)-1,9-十五碳二烯-4,6-二炔-3,8-二醇 性质
| 沸点 | 381.2±42.0 °C(Predicted) |
|---|---|
| 密度 | 1.022±0.06 g/cm3(Predicted) |
| 酸度系数(pKa) | 11.69±0.20(Predicted) |
Araliadiol 是从 Aralia cordata Thunb 的叶子中分离出来的一种聚炔化合物。Araliadiol 抑制 MCF-7 细胞生长，IC50 值为 6.41 µg/mL。
IC50: 6.41 µg/mL (MCF-7 cells growth)
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits cell cycle progression of MCF-7 at the G1-S transition.
Araliadiol (20-80 µM; 0-48 hours; MCF-7 cells) treatment inhibits phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells, accompanies by a decrease in the levels of cyclin D
3
and cdk4 and an increase in the expression of p21 (WAF-1/Cip1).
Cell Cycle Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 20 µM, 40 µM, and 80 µM |
| Incubation Time: | 0 hour, 6 hours, 12 hours, 18 hours, 24 hours, and 48 hours |
| Result: | The proportion of cells in the G1 phase of the cell cycle increased in a dose-dependent manner (from 54.7 % to 72.0 %). |
Western Blot Analysis
| Cell Line: | MCF-7 cells |
| Concentration: | 20 µM, 40 µM, and 80 µM |
| Incubation Time: | 48 hours |
| Result: | Phosphorylation of retinoblastoma protein (Rb) in MCF-7 cells was inhibited, accompanied by a decrease in the levels of cyclin D 3 and cyclin-dependent kinase 4 (cdk4) and an increase in the expression of p21 (WAF-1/Cip1). |