法倔唑
中文名称 | 法倔唑 |
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中文同义词 | 法倔唑;4-(5,6,7,8-四氢咪唑并[1,5-Α]吡啶-5-基)苯腈;AROMATASE抑制剂(FADROZOLE);4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯甲腈;4-(5,6,7,8-四氢咪唑[1,5-A]吡啶-5-基)苯腈;4-(5,6,7,8-四氢咪唑并[1,5-A]吡啶-5-基)苯腈;法曲唑(CGS16949A) |
英文名称 | FADROZOLE |
英文同义词 | FADROZOLE;4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridine-5-yl)benzonitrile;4-[(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin)-5-yl]benzonitrile;4-[[5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin]-5-yl]benzonitrile;5,6,7,8-Tetrahydro-5-(4-cyanophenyl)imidazo[1,5-a]pyridine;CGS-16949;Fadrozole Hydrochloride Hydrate;Afema |
CAS号 | 102676-47-1 |
分子式 | C14H13N3 |
分子量 | 223.27 |
EINECS号 | |
相关类别 | 抗肿瘤药;其它抗肿瘤药物;药物;细胞生物学试剂 |
Mol文件 | 102676-47-1.mol |
结构式 | ![]() |
法倔唑 性质
熔点 | 0°C |
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沸点 | 0°C |
密度 | 1.20 |
闪点 | 0°C |
储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:≥100mg/mL(447.89mM) |
酸度系数(pKa) | 7.16±0.40(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
EPA化学物质信息 | Benzonitrile, 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)- (102676-47-1) |
Target | Value |
Aromatase
() | 4.5 nM |
Fadrozole hydrochloride is a very potent inhibitor of both human placental and rat ovarian aromatase. In hamster ovarian slices, fadrozole hydrochloride inhibits the production of estrogen with an IC 50 of 0.03 μM. The production of progesterone is inhibited with an IC 50 of 120 μM. Synthesis of other cytochrome P-450 dependent steroids can be suppressed to various degrees with higher doses of fadrozole hydrochloride. .
Fadrozole hydrochloride is able to inhibit the aromatase-mediated androstenedione-induced uterine hypertrophy in immature female rats with an ED 50 of 0.03 mg/kg when given orally. In the same model, aminoglutethimide elicits the same effect with an ED 50 of 30 mg/kg when given orally. Fadrozole hydrochloride prevents the development of both benign and malignant spontaneus mammary neoplasns in female Sprague-Dawley rats. It also slows the spontaneous development of ptuitary pars dta mas in female rats, and reduces the of spontaneous hcu ar tumours in male and female rats. Administration of fadrozole in male and female mice suppresses the production of 17b-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect is associated in male mice with a recovery of the specific cellular immune response. Interleukin-6 (IL-6) serum levels, and its production by splenocytes, is augmented by 80%, together with a 10-fold increase in its expression in testes of infected male mice. Fadrozole treatment returns these levels to baseline values.
盐酸法屈唑(Fadrozole Hydrochloride):C14H13N3?HCl。[102676-96-0]。从异丙醇结晶,熔点231--233℃。溶于水。
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-14247A | 法倔唑 Fadrozole | 102676-47-1 | 5mg | 660元 |
2024/08/19 | HY-14247A | 法倔唑 Fadrozole | 102676-47-1 | 10mM * 1mLin DMSO | 726元 |