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| | Hydroxy-PEG4-t-butyl ester Basic information |
| Product Name: | Hydroxy-PEG4-t-butyl ester | | Synonyms: | HO-PEG4-CH2CH2COOTBU;Hydroxy-PEG-5-t-butyl ester;PEG5-t-butly ester;Hydroxy-PEG4-t-butly ester;OH-PEG4-CH2CH2COOtBu;OH-PEG4-TBA;HO-PEG4-COOtBu;t-Butyl 3-Hydroxy(PEG4)propoinate | | CAS: | 518044-32-1 | | MF: | C15H30O7 | | MW: | 322.39 | | EINECS: | | | Product Categories: | peg | | Mol File: | 518044-32-1.mol |  |
| | Hydroxy-PEG4-t-butyl ester Chemical Properties |
| Boiling point | 406.8±35.0 °C(Predicted) | | density | 1.04746 g/mL | | refractive index | n/D 1.4492 | | storage temp. | 2-8°C | | solubility | Soluble in Water, DCM | | form | liquid | | pka | 14.36±0.10(Predicted) | | color | Colorless to Light yellow to Light orange |
| | Hydroxy-PEG4-t-butyl ester Usage And Synthesis |
| Description | Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| | Hydroxy-PEG4-t-butyl ester Preparation Products And Raw materials |
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