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| | Hydroxy-PEG3-t-butylester Basic information |
| Product Name: | Hydroxy-PEG3-t-butylester | | Synonyms: | Hydroxy-PEG3-t-butylester;OH-PEG2-CH2CH2COOtBu;OH-PEG2-TBA;Hydroxy-PEG2-t-butyl ester;Propanoic acid, 3-[2-(2-hydroxyethoxy)ethoxy]-, 1,1-dimethylethyl ester;HO-(CH2CH2O)2-CH2CH2COOt-Bu;3-[2-(2-Hydroxyethoxy)ethoxy]propanoic Acid tert-Butyl Ester;9-Hydroxy-4,7-dioxanonanoic Acid tert-Butyl Ester | | CAS: | 133803-81-3 | | MF: | C11H22O5 | | MW: | 234.29 | | EINECS: | | | Product Categories: | peg | | Mol File: | 133803-81-3.mol |  |
| | Hydroxy-PEG3-t-butylester Chemical Properties |
| Boiling point | 321.8±22.0 °C(Predicted) | | density | 1.046±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in DMSO | | form | clear liquid | | pka | 14.36±0.10(Predicted) | | color | Colorless to Almost colorless |
| | Hydroxy-PEG3-t-butylester Usage And Synthesis |
| Description | Hydroxy-PEG2-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | Hydroxy-PEG2-(CH2)2-Boc is an ADC linker for the synthesis of antibody drug conjugates (ADC), Hydroxy-PEG2-(CH2)2-Boc is derived from patent WO2004008101A2 (compound 196). Hydroxy-PEG2-(CH2)2-Boc can also be used as a PROTAC linker for PROTAC synthesis. | | in vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker. |
| | Hydroxy-PEG3-t-butylester Preparation Products And Raw materials |
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