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| | 4,4'-DIPYRIDYL DISULFIDE Basic information |
| | 4,4'-DIPYRIDYL DISULFIDE Chemical Properties |
| Melting point | 76-78 °C(lit.) | | Boiling point | 356.1±17.0 °C(Predicted) | | density | 1.3078 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | 2-8°C | | solubility | 95% ethanol: soluble5%, clear, colorless to light yellow | | form | Crystalline Powder | | pka | 3.60±0.26(Predicted) | | color | White to orange | | BRN | 154742 | | InChIKey | UHBAPGWWRFVTFS-UHFFFAOYSA-N | | CAS DataBase Reference | 2645-22-9(CAS DataBase Reference) | | NIST Chemistry Reference | Pyridine, 4,4'-dithiobis-(2645-22-9) |
| | 4,4'-DIPYRIDYL DISULFIDE Usage And Synthesis |
| Chemical Properties | white to orange crystalline powder | | Uses | - Aldrithiol?-4 was used as cosubstrate in a study to develop highly specific inhibitors against mannose-binding lectin-associated serine proteases by in vitro evolution technology:phage display.
- It was used to study the O2 equilibria of recombinant human neuroglobin and cytoglobin measured under close to physiological conditions.
- It was used to modify gold surfaces for protein studies.
| | Definition | ChEBI: An organic disulfide obtained by formal oxidative dimerisation of 4-thiopyridine. | | Purification Methods | Recrystallise the disulfide from H2O, EtOH, Me2CO, *C6H6 or pet ether. It has been used as a 1mM solution in EtOH for the spectrophotometric estimation of thiols. Essentially the thiol displaces half the disulfide molecule liberating the 4-mercaptopyridine (4-pyridinethiol) anion, thereby shifting the max from 324nm (of the disulfide) to 285nm (of the anion) at pH 9. (Compare with 2,2’dipyridyl disulfide above which has been used for the same purpose.) [Humphrey et al. Anal Chem 40 698 1970, Cheng & Ritchie Aust J Chem 26 1785 1973.] [Beilstein 21 II 35, for review see Aldrichimica Acta 4 33 1971.] |
| | 4,4'-DIPYRIDYL DISULFIDE Preparation Products And Raw materials |
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