SR 59230A HCl
| 中文名称 | SR 59230A HCl |
|---|---|
| 中文同义词 | 化合物 T13016L;SR 59230A盐酸盐 |
| 英文名称 | SR 59230A HCl |
| 英文同义词 | SR-59230A hydrochloride,SR59230A hydrochloride |
| CAS号 | 1135278-41-9 |
| 分子式 | C21H27NO2.HCl |
| 分子量 | 361.91 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1135278-41-9.mol |
| 结构式 |  |
SR 59230A HCl 性质
| 储存条件 | Store at 4°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 颜色 | 白色 |
SR59230A hydrochloride 是一种有效，选择性的，可透过血脑屏障的 β3-肾上腺素能受体 (β3-adrenergic receptor) 拮抗剂，对 β3，β1 和 β2 受体的 IC50 分别为 40、408 和 648 nM。
IC50: 40 nM (β3 receptor), 408 nM ((β1 receptor), 648 nM (β2 receptor)
SR59230A (100 nM-50 μM; 24 hours) is able to reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines.
Cell Viability Assay
| Cell Line: | Three different neuroblastoma (NB) cell lines, one murine (Neuro-2A) and two human (SK-N-BE(2), BE(2)C) |
| Concentration: | 100 nM, 1 μM, 5 μM, 10 μM, and 50 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced cell viability in a dose-dependent manner, with significant effect at a concentration limit over 1 µM for Neuro-2A cells and 5 µM for SK-N-BE(2) and BE(2)C). |
MDMA (20 mg/kg) produces a slowly developing hyperthermia, reaching a maximum increase of 1.8°C at 130 min post injection. SR59230A (0.5 mg/kg) produces a small but significant attenuation of the slowly developing hyperthermia to MDMA. SR59230A (5 mg/kg) reveals a significant and marked early hypothermic reaction to MDMA.
| Animal Model: | Male C-57BL6J wild-type mice (22-35 g) |
| Dosage: | 0.5 or 5 mg/kg |
| Administration: | Injected s.c.; administered 30 min prior to the injection s.c. of MDMA (20 mg/kg). |
| Result: | Modulated the actions of MDMA on temperature involve α1-adrenoceptor antagonism. |