Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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Tel: |
15076683720 |
Email: |
klq@cw-bio.com |
Products Intro: |
CAS:1135278-41-9 Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| SR 59230A HCl Basic information |
| SR 59230A HCl Chemical Properties |
storage temp. | Store at 4°C | solubility | Soluble in DMSO | form | solid | color | White |
| SR 59230A HCl Usage And Synthesis |
Description | SR 59230A (hydrochloride) is a β3-adrenergic receptor (β3-AR) antagonist (pA2s = 8.76, 7.31, and 6.63 in rat proximal colon, guinea pig atrium, and guinea pig trachea, respectively). It is less selective for β3-AR in cells transfected with the human β-AR subtypes (Kis = 16.4, 61.9, and 122 nM for β1-, β2-, and β3-AR, respectively). At low concentrations, SR 59230A blocks MDMA-induced hyperthermia, while at high concentrations it blocks hyperthermia but also increases heat loss through an α1-AR antagonistic mechanism. In adipocytes, it induces phosphorylation of p38 MAPK via the Gs pathway. It has also been used in studies of heart failure to elucidate the role of the β3-ARs. | Uses | SR 59230A Hydrochloride is a potent and selective β3 adrenergic receptor antagonist. | storage | Store at RT |
| SR 59230A HCl Preparation Products And Raw materials |
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