66225-78-3
中文名称 | 66225-78-3 |
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中文同义词 | 甘氨酸-多酚酸;化合物 T11426 |
英文名称 | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid |
英文同义词 | 2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid;2-((4R)-4-((3R,5R,6S,7R,10R,13R)-3,6,7-Trihydroxy-10,13-Dimethylhexadecahydro-1H-Cyclopenta[A]Phenanthren-17-Yl)Pentanamido)Acetic Acid(WXC04817);Glycine--Muricholic Acid;N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine;Glyco-?-Muricholic Acid;Glycine-β-muricholic acid (GβMCA);Gly-β-MCA;Glycine-β-muricholic Acid |
CAS号 | 66225-78-3 |
分子式 | C26H43NO6 |
分子量 | 465.62 |
EINECS号 | |
相关类别 | 生化试剂;小分子 |
Mol文件 | 66225-78-3.mol |
结构式 | ![]() |
66225-78-3 性质
沸点 | 673.4±55.0 °C(Predicted) |
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密度 | 1.213±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
溶解度 | DMF:30 mg/ml; DMF:PBS(pH 7.2)(1:1):0.5 mg/ml; DMSO:20 mg/ml;乙醇:20 mg/ml |
形态 | 结晶固体 |
酸度系数(pKa) | 3.58±0.10(Predicted) |
颜色 | 白色至米白色 |
FXR.
Gly-β-MCA, a bile acid, is a potent, sable and intestine-selective and farnesoid X receptor (FXR) inhibitor.
Gly-β-MCA (Gly-MCA, ) is resistant to hydrolysis by BSH.
Gly-β-MCA (Gly-MCA, p.o. 10 and 50 mg/kg) prevents and treats diet-induced and genetic obesity, along with insulin resistance and hepatic steatosis without systemic, hepatic or intestinal toxicities in mice.
Gly-MCA does not increase faecal LCN-2 levels, indicating that Gly-MCA does not induce intestinal inflammation.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-114392 | Gly-β-MCA | 1 mg | 1705元 | |
2024/04/30 | HY-114392 | 66225-78-3 Gly-β-MCA | 66225-78-3 | 5mg | 3750元 |