Volixibat potassium
中文名称 | Volixibat potassium |
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中文同义词 | 单链尿激酶纤溶酶原激活剂八肽;化合物 T26629;单链尿激酶纤溶酶原激活剂多肽;多肽ANGSTROM6;(S)-N-((S)-1-氨基-3-(4-羟基苯基)-1-氧代丙烷-2-基)-2-((S)-2-((S)-2-((S)-2-((S)-2-氨基-3-苯基丙酰胺基)-3-羟基丙酰胺基)-4-甲基戊酰胺)-4-甲基戊酰胺)-5-胍基戊酰胺 |
英文名称 | Volixibat potassium |
英文同义词 | Volixibat potassium;Angstrom6/A6 Peptide;A-6 peptide;L-α-Glutamine, N2-acetyl-L-lysyl-L-prolyl-L-seryl-L-seryl-L-prolyl-L-prolyl-L-α-glutamyl-;P1161 Angstrom6;A-6|||A 6 peptide|||A6|||A 6|||A6 peptide|||A-6 peptide;(S)-N-((S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)-2-((S)-2-((S)-2-((S)-2-((S)-2-amino-3-phenylpropanamido)-3-hydroxypropanamido)-4-methylpentanamido)-4-methylpentanamido)-5-guanidinopentanamide |
CAS号 | 220334-14-5 |
分子式 | C39H62N10O15 |
分子量 | 910.98 |
EINECS号 | |
相关类别 | 定制多肽 |
Mol文件 | 220334-14-5.mol |
结构式 |
Volixibat potassium 性质
沸点 | 1469.3±65.0 °C(Predicted) |
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密度 | 1.409±0.06 g/cm3(Predicted) |
储存条件 | Store at -20°C |
酸度系数(pKa) | 4.44±0.10(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
Angstrom6 is effective at blocking the migration of the OVCAR8, OVCAR3, ES2, IGROV-1, MDA-MB-468, and MDA-MB361 cells with IC
50
s in the range of 10 to 100 nM.
Angstrom6 potentiates the CD44-dependent adhesion of cancer cells to hyaluronic acid and activated CD44-mediated signaling, as evidenced by focal adhesion kinase and MAP/ERK kinase phosphorylation.
Angstrom6 (100 mg/kg; s.c. twice daily) reduces the number of lung foci generated by the i.v. injection of B16-F10 melanoma cells by 50%.
Animal Model: | C57Bl/6 mice (bearing B16-F10 cells) |
Dosage: | 100 mg/kg |
Administration: | S.c.; twice a day for 11 days |
Result: | Reduced the number of lung nodules and reduced the number of lung metastases to 50% of control. |