|
|
| | Propargyl-PEG4-S-PEG4-acid Basic information |
| Product Name: | Propargyl-PEG4-S-PEG4-acid | | Synonyms: | Propargyl-PEG4-S-PEG4-acid;4,7,10,13,19,22,25,28-Octaoxa-16-thiahentriacont-30-ynoic acid;3-[2-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethylsulfanyl]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid | | CAS: | 2055041-20-6 | | MF: | C22H40O10S | | MW: | 496.61 | | EINECS: | | | Product Categories: | | | Mol File: | 2055041-20-6.mol |  |
| | Propargyl-PEG4-S-PEG4-acid Chemical Properties |
| Boiling point | 591.5±50.0 °C(Predicted) | | density | 1.141±0.06 g/cm3(Predicted) | | pka | 4.28±0.10(Predicted) |
| | Propargyl-PEG4-S-PEG4-acid Usage And Synthesis |
| Description | Propargyl-PEG4-S-PEG4-acid is a PEG linker containing a propargyl group with a terminal carboxylic acid. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) forming a stable amide bond. The propargyl groups can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield stable triazole linkages. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | Propargyl-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG4-S-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG4-S-PEG4-acid Preparation Products And Raw materials |
|