| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Company Name: |
Biolab Reagents |
| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
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| Product Name: | IGM | | Synonyms: | phosphatidylinositol antibody IgG;IGM;IMMUNOGLOBULIN M;Purified Anti-Human CD154 Antibody[24-31;hCD40L;HIGM1;IMD3;T-BAM | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![IGM Structure]() |
| Clinical Use | IgM (Fc = μ) is present at a concentration ofabout 1.5 mg/mL and has a half-life of less than 1 week. ThisAb participates in opsonization, agglutination reactions, andcomplement fixation. Opsonization, as stated previously, is a“protein coating” or tagging of a bacterium that renders itmore susceptible to phagocytosis. A complex of the Fc portionof IgM plus C3b of complement is that protein. IgM isthe first immunoglobulin formed during immunization, but itwanes and gives way to IgG. IgM is a pentamer, and its agglutinationpotency is about 1,000 times that of IgG. IgM isalso responsible for the A, B, and O blood groups. The fundamentalmonomeric IgM structure is much like that of IgG.The pentamer is held together by disulfide bonds and a singleJ (joining) peptide. The affinity of an IgM monomer forantigen is less than that of IgG, but the multimeric structureraises the avidity of the molecule for an antigen. |
| | IGM Preparation Products And Raw materials |
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