158364-59-1
| 中文名称 | 158364-59-1 |
|---|---|
| 中文同义词 | 普马拉唑;化合物 T16682;(2-(((2,3-二甲基咪唑并[1,2-A]吡啶-8-基)氨基)甲基)-3-甲基苯基)氨基甲酸甲酯 |
| 英文名称 | Carbamic acid,N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]-,methyl ester |
| 英文同义词 | Carbamic acid,N-[2-[[(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino]methyl]-3-methylphenyl]-,methyl ester;PUMAPRAZOLE;inhibit,Proton Pump,BY 841,Pumaprazole,BY841,Inhibitor;Methyl (2-(((2,3-dimethylimidazo[1,2-a]pyridin-8-yl)amino)methyl)-3-methylphenyl)carbamate |
| CAS号 | 158364-59-1 |
| 分子式 | C19H22N4O2 |
| 分子量 | 338.4 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 158364-59-1.mol |
| 结构式 |  |
158364-59-1 性质
| 密度 | 1.21±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 形态 | 固体 |
| 酸度系数(pKa) | 13.67±0.70(Predicted) |
| 颜色 | 浅黄至黄色 |
Pumaprazole 是一种可逆性质子泵拮抗剂。
proton pump
Pumaprazole is a reversible proton pump antagonist. Basal acid secretion in the Ghosh-Schild rat is inhibited by Pumaprazole with a higher efficacy compare to ranitidine. Pumaprazole displays identical ID 50 values on day 1 (11 μmol/kg, 95% confidence limits of 5 and 23) and on day 7 (10 μmol/kg, 95% confidence limits of 4 and 23) of a repeated dose study in this model. The lower dose of Pumaprazole (27 μmol/kg) rapidly elevates luminal pH up to almost neutrality, the higher dose (54 μmol/kg) further prolongs this pH-elevating effect.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-19223 | 普马拉唑 Pumaprazole | 158364-59-1 | 1mg | 3000元 |
| 2024/08/19 | HY-19223 | 普马拉唑 Pumaprazole | 158364-59-1 | 5mg | 6900元 |