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| | CU-CPT-9a Basic information |
| Product Name: | CU-CPT-9a | | Synonyms: | CPD1577;CU-CPT-9a;2-Methyl-4-(7-hydroxy-4-quinolinyl)phenol;cas 2162962-69-6;CU-CPT-9A;CAS 2162962-69-6;TLR8 INHIBITOR;TLR8 inhibitor;TLR8-specific antagonist 1;4-(4-hydroxy-3-methylphenyl)quinolin-7-ol | | CAS: | 2162962-69-6 | | MF: | C16H13NO2 | | MW: | 251.28 | | EINECS: | | | Product Categories: | | | Mol File: | 2162962-69-6.mol |  |
| | CU-CPT-9a Chemical Properties |
| Boiling point | 452.6±45.0 °C(Predicted) | | density | 1.287±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 8.46±0.20(Predicted) | | color | White to yellow |
| | CU-CPT-9a Usage And Synthesis |
| Description | CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressing HEK-Blue cells with an IC50 value of 0.7 nM. | | Uses | CU-CPT9a is a potent TLR8 inhibitor (IC50 = 0.5 nM and Kd = 21 nM). Stabilizes the TLR8 dimer in its resting state, preventing activation. Suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells. |
| | CU-CPT-9a Preparation Products And Raw materials |
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