| Company Name: |
Hubei Jusheng Technology Co.,Ltd. |
| Tel: |
18871490254 |
| Email: |
linda@hubeijusheng.com |
| Products Intro: |
Product Name:(3S,5S,9R,10S,13R,14R,17R)-17-[(E,2R,5S)-5-ethyl-6-methylhept-3-en-2-yl]-10,13-dimethyl-2,3,4,5,6,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
CAS:481-18-5
Purity:0.99 Package:5KG;1KG
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- α-Spinasterol
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- $40.00 / 1mg
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2024-11-19
- CAS:481-18-5
- Min. Order:
- Purity: 99.58%
- Supply Ability: 10g
- A-SPINASTEROL
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- $1.00 / 1KG
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2020-01-05
- CAS:481-18-5
- Min. Order: 1KG
- Purity: 95-99%
- Supply Ability: 1ton
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| | A-SPINASTEROL Basic information |
| Product Name: | A-SPINASTEROL | | Synonyms: | alpha-spinasterin;spinasterol;DELTA7-STIGMASTEROL;(24R)-5α-Stigmasta-7,22-dien-3β-ol;Hitdesterol;(22E)-5α-Stigmasta-7,22-dien-3β-ol;-amine D2;HITODESTEROL | | CAS: | 481-18-5 | | MF: | C29H48O | | MW: | 412.69 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 481-18-5.mol |  |
| | A-SPINASTEROL Chemical Properties |
| Melting point | 168-169° | | alpha | D25 -3.6° (c = 2.8 in chloroform) | | Boiling point | 500.0±44.0 °C(Predicted) | | density | 0.98±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 15.10±0.70(Predicted) | | color | White to Off-White | | biological source | Aster scaber | | Stability: | Light Sensitive |
| | A-SPINASTEROL Usage And Synthesis |
| Uses | α-Spinasterol was identified as a novel transient receptor potential vanilloid 1 antagonist with antinociceptive properties. | | Definition | ChEBI: Alpha-Spinasterol is a steroid. It derives from a hydride of a stigmastane. | | Biological Activity | α-Spinasterol is a blood-brain barrier-permeable and orally active plant phytosterol with antioxidant, anticonvulsant (0.1-1 mg/kg i.p. in mice), antidepressant (1-2 mg/kg i.p. in mice) and anti-inflammatory (0.001-1 mg/kg, i.p. or 1-10 mg/kg, i.g. in mice) properties, as well as antinociceptive efficacy via dual actions against transient receptor potential vanilloid 1 (TrpV1; IC50/Emax = 1.4 μM/67% against 2 nM RTX for binding mouse spinal cord membranes; IC50/Emax = 40 μM/62% against 20 μM capsaicin-induced mouse spinal cord synaptosomes Ca2+ influx) and cyclooxygenases (IC50 = 16.17 μM/COX1 and 7.76μM/COX2). a-spinasterol can directly affect membrane structure and packing in a manner similar to cholesterol, both a-spinasterol and stitosterol are reported to lower plasma/liver cholesterol levels and increase fecal cholesterol excretion when supplemented in daily diet (1%) in mice in vivo.', 'α-Spinasterol is a constituent of argan oil. It regulates nuclear receptors expression and modulates mitochondrial function. It mimics natural cholesterol and its functionality. α-Spinastero lelicits cytoprotective and antiulcerogenic functionality. It has therapeutic potential towards diabetic nephropathy. | | target | TRPV | HMG-CoA reductase |
| | A-SPINASTEROL Preparation Products And Raw materials |
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