Fmoc-Trp(Boc)-OH

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Fmoc-Trp(Boc)-OH manufacturers

Fmoc-Trp(Boc)-OH Unveiled: A Comprehensive Exploration of its Role and Applications in Peptide Chemistry
This review delves into the characteristics, synthesis, and applications of Fmoc-Trp(Boc)-OH, and its role in peptide synthesi....
Sep 23，2024

Fmoc-Trp(Boc)-OH Basic information

Product Name:	Fmoc-Trp(Boc)-OH
Synonyms:	FMOC-TRP(BOC)-OH;FMOC-TRYPTOPHAN(BOC)-OH;FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN;FMOC-N-IN-BOC-L-TRYPTOPHAN;FMOC-N-BOC-L-TRYPTOPHAN;FMOC-L-TRYPTOPHAN(BOC);FMOC-L-TRYPTOPHAN (TBOC);FMOC-L-TRP(TBOC)-OH
CAS:	143824-78-6
MF:	C31H30N2O6
MW:	526.58
EINECS:	604-383-0
Product Categories:	Tryptophan [Trp, W];Fmoc-Amino Acids and Derivatives;Amino Acids;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series
Mol File:	143824-78-6.mol

Fmoc-Trp(Boc)-OH Chemical Properties

Melting point	ca 97℃
alpha	-21 º (c=1%, DMF)
density	1.28±0.1 g/cm3(Predicted)
refractive index	-20 ° (C=1, DMF)
storage temp.	2-8°C
solubility	Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form	Solid
pka	3.71±0.10(Predicted)
color	White to Orange to Green
optical activity	[α]20/D 21±2°, c = 1% in DMF
Sensitive	Moisture Sensitive
BRN	7698009
InChIKey	ADOHASQZJSJZBT-SANMLTNESA-N
SMILES	C(O)(=O)[C@H](CC1C2=C(C=CC=C2)N(C(OC(C)(C)C)=O)C=1)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	143824-78-6(CAS DataBase Reference)

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

Fmoc-Trp(Boc)-OH Usage And Synthesis

Chemical Properties	White solid
Uses	Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS).
Uses	Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides.
General Description	The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide. The product number for this product was previously 04-12-1103. To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
reaction suitability	reaction type: Fmoc solid-phase peptide synthesis

Fmoc-Trp(Boc)-OH Preparation Products And Raw materials

Preparation Products

Tag:Fmoc-Trp(Boc)-OH(143824-78-6) Related Product Information

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