- Doxacurium chloride
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- $0.00 / 1Kg
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2023-07-07
- CAS:106819-53-8
- Min. Order: 1Kg
- Purity: 99%；USP/EP/CP
- Supply Ability: 1-10000kgs
- Docusate Sodium
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- $15.00 / 1KG
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2021-07-02
- CAS:106819-53-8
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | DOXACURIUM CHLORIDE Basic information | | Reaction |
| Product Name: | DOXACURIUM CHLORIDE | | Synonyms: | DOXACURIUM CHLORIDE;Doxacurium;BW-A938U;Nuromax;bis[3-[6,7,8-trimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]-3,4-dihydro-1h-isoquinolin-2-ium-2-yl]propyl] butanedioate dichloride;DOXACURIUM CHLORIDE USP/EP/BP | | CAS: | 106819-53-8 | | MF: | C56H78Cl2N2O16 | | MW: | 1106.13 | | EINECS: | | | Product Categories: | | | Mol File: | 106819-53-8.mol |  |
| | DOXACURIUM CHLORIDE Chemical Properties |
| | DOXACURIUM CHLORIDE Usage And Synthesis |
| Reaction | Ligand for the palladium catalyzed aqueous Lipshutz-Negishi cross-coupling of alkyl halides with aryl electrophiles.
| | Description | Doxacurium chloride is an injectable, noncumulative, nondepolarizing neuromuscular
blocking agent which exhibits no significant cardiovascular effects. It is a mixture of
(lR, l′S, 2S, 2′R), (lR, l′R, 2S, 2′s) and (lS, l′S, 2R, 2′R) isomers of a
bis-benzylisoquinolinium diester.Doxacurium chloride provides satisfactory
intubation with duration of action similar to d-tubocurarine or pancuronium. However,
it is reported to be 2 to 3 times as potent as pancuronium. | | Originator | Wellcome (United Kingdom) | | Uses | Neuromuscular blocking agent. | | Uses | Doxacurium Chloride is a nondepolarizing neuromuscular blocking agent that is minimally hydrolyzed by human plasma cholinesterase. | | Brand name | Nuromax (Abbott). | | General Description | The molecular structure of doxacuriumchloride, 1,2,3,4-tetrahydro-2-(3-hydroxypropyl)-6,7,8-trimethoxy2-methyl-1-(3,4,5-trimethoxybenzyl) isoquinoliniumchloride succinate (Nuromax), provides thepossibility for 10 stereoisomers: 4 d,l pairs and two mesoforms. Of the 10 stereoisomers, 3 are all-trans configuration,and these are the only active ones. Doxacurium chlorideis a long-acting nondepolarizing blocking agent. The drugdiffers from drugs such as gallium and pancuronium in thatit has no vagolytic activity. It is used as a skeletal musclerelaxant in surgical procedures expected to last longer than90 minutes. | | Pharmacokinetics | Doxacurium is a mixture of three trans, trans-stereoisomers, a dl pair [(1R,1′R,2S,2′S) and (1S,1′S,2R,2′R)] and a meso form (1R,1′S,2S,2′R).
Doxacurium is hydrophilic, has a small volume of distribution, and is distributed primarily to extracellular fluids. It is not metabolized by plasma
cholinesterase or hepatic enzymes and does not undergo Hofmann elimination. |
| | DOXACURIUM CHLORIDE Preparation Products And Raw materials |
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