Balsalazide disodium manufacturers
- Balsalazide disodium
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- $0.00 / 1kg
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2025-04-17
- CAS:150399-21-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 20tons
- Balsalazide disodium
-
- $150.00 / 1kg
-
2025-04-17
- CAS:150399-21-6
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 500kg
- Balsalazide disodium
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- $0.00 / 25KG
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2025-03-21
- CAS:150399-21-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
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| | Balsalazide disodium Basic information |
| Product Name: | Balsalazide disodium | | Synonyms: | BALSALAZIDE DISODIUM SALT DIHYDRATE;BALSALAZIDE DISODIUM DIHYDRATE;BALSALAZIDE SODIUM;BALSALZIDE DISODIUM;(E)-5-[[4-[[(2-CARBOXYETHYL)AMINO]CARBONYL]PHENYL]AZO]-2-HYDROXYBENZOIC ACID, DISODIUM SALT, DIHYDRATE;BALSALAZIDE DISODIUM 2-HYDRATE;BALSALAZIDEDISODOUMSALT;(E)-5-[[4-[[(2-Carboxyethyl)amino]-carbonyl]phenyl]azo-2-hydroxy-benzoic acid disodium salt | | CAS: | 150399-21-6 | | MF: | C17H18N3NaO7 | | MW: | 399.33 | | EINECS: | 1533716-785-6 | | Product Categories: | COLAZAL;Intermediates | | Mol File: | 150399-21-6.mol |  |
| | Balsalazide disodium Chemical Properties |
| Melting point | >195°C (dec.) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) | | form | Solid | | color | Yellow | | Merck | 14,945 | | InChIKey | XDCNKOBSQURQOZ-MVIJUDHYSA-L |
| | Balsalazide disodium Usage And Synthesis |
| Uses | antiinflammatory | | Uses | Balsalazide Disodium Dihydrate is an analogue of Sulfasalazine (S699084), A prodrug of 5-aminosalicylic acid where carrier molecule is 4-aminobenzoyl-β-alanine. Anti-inflammatory (gastrointestinal). | | Indications | Balsalazide disodium is delivered intact to the colon, where it is
cleaved by bacterial azoreduction to release equimolar
quantities of mesalamine, the therapeutically active
portion of the molecule, and 4-aminobenzoyl-β-alanine;
the latter compound is only minimally absorbed and is
largely inert. | | Definition | ChEBI: The dihydrate of the disodium salt of balsalazide. A prodrug, releasing the anti-inflammatory 5-aminosalicylic acid (mesalazine) in the large intestine, it is used in the treatment of ulcerative colitis. | | Brand name | Colazal
(Salix). | | in vivo | At the endpoint, the protein production of MIP-1β, MCP-1, IL-6, and IL-10 in the colon tissues decrease in concordance with the plasma concentrations of the cytokines. The drug-treated groups reveal lower expression of p-STAT3 compared to the CAC group. In addition, BCL2 decreases and BAX increases markedly in the BSZ+VSL#3 group[1]. Balsalazide is a new 5-aminosalicylic acid (5-ASA) containing prodrug[2]. | | IC 50 | IL-6; IL-1; STAT3 |
| | Balsalazide disodium Preparation Products And Raw materials |
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