N-OMEGA-PROPYL-L-ARGININE
| 中文名称 | N-OMEGA-PROPYL-L-ARGININE |
|---|---|
| 中文同义词 | |
| 英文名称 | N-OMEGA-PROPYL-L-ARGININE |
| 英文同义词 | L-N5-(1-IMINO-9-PROPYLAMINO-O-METHYL)ORINTHINE;L-N5-(1-IMINO(PROPYLAMINO))METHYL-ORNITHINE;2(S)-2-AMINO-5-(N-PROPYLGUANIDINO)PENTANOIC ACID;N5-[IMINO(PROPYLAMINO)METHYL]-L-ORNITHINE;NW-PROPYL-L-ARGININE;N-PLA;N-OMEGA-PROPYL-L-ARGININE;NG-PROPYL-L-ARGININE |
| CAS号 | 137361-05-8 |
| 分子式 | C9H20N4O2 |
| 分子量 | 216.28 |
| EINECS号 | |
| 相关类别 | All Inhibitors;Inhibitors;Nitric Oxide Reagents;Amino Acids & Derivatives |
| Mol文件 | 137361-05-8.mol |
| 结构式 |  |
N-OMEGA-PROPYL-L-ARGININE 性质
| 熔点 | 198-200?C |
|---|---|
| 沸点 | 366.5±52.0 °C(Predicted) |
| 密度 | 1.24±0.1 g/cm3(Predicted) |
| 储存条件 | Desiccate at RT |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 酸度系数(pKa) | 2.50±0.24(Predicted) |
| 形态 | 白色至类白色固体。 |
| 颜色 | 白色 |
| 稳定性 | 非常吸湿 |
| CAS 数据库 | 137361-05-8(CAS DataBase Reference) |
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) 是一种高效、竞争性、高选择性的神经型一氧化氮合酶 (nNOS) 抑制剂，Ki为 57 nM。Nω-Propyl-L-arginine 对 nNOS 的选择性是内皮型一氧化氮合酶 (eNOS) 的 149 倍。
Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity.
| Animal Model: | Male NMRI mice (30-40 g) (phencyclidine-induced stimulation) |
| Dosage: | 20 mg/kg |
| Administration: | I.p. |
| Result: | Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/08/19 | HY-102062A | N-OMEGA-PROPYL-L-ARGININE Nω-Propyl-L-arginine hydrochloride | 137361-05-8 | 5mg | 940元 |
| 2024/08/19 | HY-102062A | N-OMEGA-PROPYL-L-ARGININE Nω-Propyl-L-arginine hydrochloride | 137361-05-8 | 10mg | 1500元 |