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| | N-OMEGA-PROPYL-L-ARGININE Basic information |
| | N-OMEGA-PROPYL-L-ARGININE Chemical Properties |
| Melting point | 198-200?C | | Boiling point | 366.5±52.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | Desiccate at RT | | solubility | Chloroform (Slightly), Methanol (Slightly) | | pka | 2.50±0.24(Predicted) | | form | White to off-white solid. | | color | White | | Stability: | Very Hygroscopic | | CAS DataBase Reference | 137361-05-8(CAS DataBase Reference) |
| | N-OMEGA-PROPYL-L-ARGININE Usage And Synthesis |
| Description | Nω-Propyl-L-Arginine is a potent and selective inhibitor of neuronal nitric oxide synthase (nNOS). Nω-Propyl-L-Arginine is a competitive inhibitor of bovine nNOS having a Ki value of 57 nM. The Ki values for eNOS (bovine) and iNOS (murine) are 8.5 and 180 μM, respectively. Nω-propyl-L-Arginine therefore exhibits 3,000-fold and 150-fold selectivity for the neuronal isoform versus the inducible (murine) and endothelial (bovine) isoforms of NOS, respectively. | | Chemical Properties | Off-White Solid | | Uses | A highly selective competitive inhibitor and inactivator of all three isoforms of NOS. | | Uses | Nω-Propyl-L-Arginine is a neuronal selective nitric oxide synthase inhibitor (1) and a highly selective competitive inhibitor and inactivator of all three isoforms of NOS (2,3). | | Biological Activity | Highly selective and potent inhibitor of nNOS (K i = 57 nM). Displays 3158-fold and 149-fold selectivity over iNOS and eNOS respectively. Hypotensive in vivo . | | storage | room temperature (desiccate) |
| | N-OMEGA-PROPYL-L-ARGININE Preparation Products And Raw materials |
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