ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >DNA damage >PARP inhibitors >PJ-34

PJ-34

PJ-34 Suppliers list
Company Name: Hangzhou FandaChem Co.,Ltd.
Tel: +8615858145714
Email: FandaChem@Gmail.com
Products Intro: Product Name:PJ34;PJ-34
CAS:344458-19-1
Purity:As coa Package:As request Remarks:344458-19-1
Company Name: Biochempartner
Tel: 0086-13720134139
Email: candy@biochempartner.com
Products Intro: Product Name:PJ-34
CAS:344458-19-1
Purity:98% HPLC LCMS Package:10G;20G
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PJ34
CAS:344458-19-1
Purity:99.85% Package:10mg;30USD|25mg;53USD|50mg;89USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Career Henan Chemica Co
Tel: +86-0371-86658258 +8613203830695
Email: laboratory@coreychem.com
Products Intro: Product Name:2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide
CAS:344458-19-1
Purity:95%-99% crystal Liu Package:1KG;0.01USD
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Products Intro: Product Name:PJ-34
CAS:344458-19-1
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer

PJ-34 manufacturers

  • PJ34
  • PJ34 pictures
  • $48.00 / 10mg
  • 2024-11-19
  • CAS:344458-19-1
  • Min. Order:
  • Purity: 99.85%
  • Supply Ability: 10g
PJ-34 Basic information
Product Name:PJ-34
Synonyms:N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide;N-(6-OXO-5,6-DIHYDRO-PHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HCL;N-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)-N,N-DIMETHYLACETAMIDE HYDROCHLORIDE;PJ-34;PJ34(free base);Acetamide, N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino)-;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide PJ 34;N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-2-(N,N-dimethylamino)acetamide
CAS:344458-19-1
MF:C17H17N3O2
MW:295.34
EINECS:604-604-1
Product Categories:Inhibitors
Mol File:Mol File
PJ-34 Structure
PJ-34 Chemical Properties
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO
form Solid
color Light yellow to khaki
Safety Information
MSDS Information
PJ-34 Usage And Synthesis
DefinitionChEBI: PJ34 is a member of the class of phenanthridines that is 5,6-dihydrophenanthridine substituted at positions 2 and 6 by (N,N-dimethylglycyl)amino and oxo groups, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 110 nM and 86 nM, respectively) and exhibits anti-cancer, cardioprotective and neuroprotective properties. It has a role as an EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor, an antineoplastic agent, an apoptosis inducer, an angiogenesis inhibitor, an antiatherosclerotic agent, a cardioprotective agent, an anti-inflammatory agent and a neuroprotective agent. It is a member of phenanthridines, a secondary carboxamide and a tertiary amino compound. It is a conjugate base of a PJ34(1+).
Enzyme inhibitorThis PARP inhibitor (FWfree-base = 295.34 g/mol; FWhydrochloride = 331.80 g/mol), systematically named N-(6-oxo-5,6-dihydro-phenanthridin-2-yl)- N,N-dimethylacetamide and known for its activity in neuroprotection under stress conditions, exclusively eradicates multi-centrosomal human mammary, colon, lung, pancreas, ovarian cancer cells, by acting as an extracentrosome extracentrosome( s) de-clustering agent in mitosis. When applied at 20-30 μM, PJ-34 caused G2/M-arrest and a massive cell death Normal human proliferating endothelial, epithelial and mesenchymal cells were unaffected. PJ-34’s cytotoxicity on cancer cells is not attributable to PARP inhibition alone. PJ-34 was originally designed to protect neuronal cells in the central nervous system from cell death evoked by high activity of PARP-1 in response to DNA damage caused by brain injury, stroke or inflammation. Targets: extra-centrosome de-clustering; polyADP-ribose polymerase-1, EC50 = 20 nM
PJ-34 Preparation Products And Raw materials
Tag:PJ-34(344458-19-1) Related Product Information
1-[[4-[(4-Fluoro-2-methyl-1H-indol-5-yl)oxy]-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yl]oxy]-2-propanol Bortezomib Y27632 (hydrochloride) Stattic CP-724714 Veliparib Olaparib