- Scoparone
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- $43.00 / 5mg
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2024-11-19
- CAS:120-08-1
- Min. Order:
- Purity: 99.93%
- Supply Ability: 10g
- 6,7-Dimethoxycoumarin
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- $0.00 / 20mg
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2023-02-24
- CAS:120-08-1
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- 6,7-Dimethoxycoumarin
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- $0.00 / 20mg
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2023-02-24
- CAS: 120-08-1
- Min. Order: 5mg
- Purity: Analytical Standard
- Supply Ability: 10 g
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| | SCOPARONE Basic information |
| | SCOPARONE Chemical Properties |
| Melting point | 143-145 °C (lit.) | | Boiling point | 265.04°C (rough estimate) | | density | 1.0858 (rough estimate) | | refractive index | 1.4389 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | >8.4mg/mL in DMSO | | form | Powder | | color | Light yellow to yellow | | Merck | 13,8479 | | LogP | 1.331 (est) | | CAS DataBase Reference | 120-08-1(CAS DataBase Reference) | | NIST Chemistry Reference | 2H-1-benzopyran-2-one, 6,7-dimethoxy-(120-08-1) |
| | SCOPARONE Usage And Synthesis |
| Uses | Scoparone-13C2D6 is a by-product in the synthesis of Scopoletin-13C,d3 (S200502). Scopoletin-13C,d3, is the labeled analogue of Scopoletin (S200500), used for cosmetics, topical formulations, and foods. Scoparone-13C2D6 is also the labeled form of Scoparone (S199980), which regulates the expression of Th1/Th2 cytokines and IgE and is effective in treating allergic rhinitis. | | Definition | ChEBI: Scoparone is a member of the class of coumarins that is esculetin in which the two hydroxy groups at positions 6 and 7 are replaced by methoxy groups. It is a major constituent of the Chinese herbal medicine Yin Chen Hao, and exhibits a variety of pharmacological activities such as anti-inflammatory, anti-allergic, and anti-tumor activities. It has a role as a plant metabolite, an anti-inflammatory agent, an antilipemic drug, an immunosuppressive agent, an antihypertensive agent and an anti-allergic agent. It is a member of coumarins and an aromatic ether. It is functionally related to an esculetin. | | Synthesis Reference(s) | Synthesis, p. 1026, 1986 DOI: 10.1055/s-1986-31859 | | General Description | 6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported. | | Safety Profile | Poison by ingestion and
intraperitoneal routes. Experimental
reproductive effects. An anthypertensive
agent. When heated to decomposition it
emits acrid smoke and irritating fumes. |
| | SCOPARONE Preparation Products And Raw materials |
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