- TRAM-34
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- $3.00 / 1KG
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2020-02-01
- CAS:289905-88-0
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 100KG
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| | TRAM-34 Basic information |
| | TRAM-34 Chemical Properties |
| Melting point | 145-147°C | | storage temp. | 2-8°C | | solubility | DMSO: ~11 mg/mL | | form | solid | | color | off-white | | Water Solubility | Soluble in DMSO at 2mg/ml. Insoluble in water | | CAS DataBase Reference | 289905-88-0 |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | TRAM-34 Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Definition | ChEBI: TRAM-34 is an organochlorine compound. | | Biological Activity | Highly selective blocker of intermediate conductance Ca 2+ -activated K + channels (IK Ca 1, K Ca 3.1) (K d = 20 nM). Exhibits 200-1500-fold selectivity over K V , BK Ca , SK Ca , Na + , CRAC and Cl - channels. Suppresses the reactivation of lymphocytes by mitogenic stimuli. | | Biochem/physiol Actions | TRAM-34 exhibits 100-fold selectivity (Kd = 20 nM) for IKCa1 channels over other K+ channels (Charybdotoxin, Kd = 5 nM, Clotrimazole, Kd = 70 nM; Nitrendipine Kd = 900 nM). Furthermore, TRAM-34 is known to suppress the activation of human T lymphocytes,. | | storage | +4°C |
| | TRAM-34 Preparation Products And Raw materials |
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