- Piperidine-2,4-dione
-
- $200.00 / 1KG
-
2024-01-02
- CAS:50607-30-2
- Min. Order: 1KG
- Purity: 99%, 99.5% Sublimated
- Supply Ability: g-kg-tons, free sample is available
- 2,4-Piperadinedione
-
- $1.00 / 1KG
-
2019-07-06
- CAS:50607-30-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: Customized
- 2,4-PiperadinedioneE
-
- $1.00 / 1KG
-
2019-07-06
- CAS:50607-30-2
- Min. Order: 1KG
- Purity: 97%
- Supply Ability: 200KG
|
| | 2,4-Piperadinedione Basic information |
| Product Name: | 2,4-Piperadinedione | | Synonyms: | piperidine-2,4-dione, dihydropyridine-4,6-dione, 2,4-dioxopiperidine, 2,4-piperidinedione, piperidin-2,4-dione, 2,4-diketopiperidine, Piperidine-2,4-dione;2,4-PIPERADINEDIONE;2,4-Piperidinedione;dihydropyridine-4,6-dione;2,4-Dioxopiperidine;2,4-Piperidinedione, 95+%;2,4-Diketopiperidine;2,4-PiperadinedioneE | | CAS: | 50607-30-2 | | MF: | C5H7NO2 | | MW: | 113.11 | | EINECS: | 803-771-9 | | Product Categories: | Pharmaceutical intermediate;Heterocycles series | | Mol File: | 50607-30-2.mol |  |
| | 2,4-Piperadinedione Chemical Properties |
| Melting point | 98.0 to 102.0 °C | | Boiling point | 362.1±35.0 °C(Predicted) | | density | 1.184±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | pka | 12.00±0.70(Predicted) | | color | White to Orange to Green | | InChI | InChI=1S/C5H7NO2/c7-4-1-2-6-5(8)3-4/h1-3H2,(H,6,8) | | InChIKey | RDNZDMDLRIQQAX-UHFFFAOYSA-N | | SMILES | N1CCC(=O)CC1=O |
| | 2,4-Piperadinedione Usage And Synthesis |
| Description | 2,4-Piperidinedione is an important piperidine ring-containing intermediate, and its 2,4-piperidinedione, as a characteristic fragment, is widely used as an intermediate in the synthesis of ibrutinib and paliperidone drugs. | | Chemical Properties | White to light yellow solid | | Uses | 2,4-Piperidinedione is a reactant in the synthesis of 1,4-dihydropyridines as TGFβ/Smad inhibitors. | | Preparation | The synthesis of 2,4-Piperidinedione involved dissolving 400 mg (2.34 mmol, 1.00 eq.) of Methyl 2,4-dioxo-piperidine-3-carboxylate in a mixture of acetonitrile (20 mL) and water (0.2 mL). The solution was then heated to approximately 86° C. and maintained at this temperature for around 4 hours. After completion of the reaction, the solvent was removed under vacuum, leaving behind a residue of 2,4-Piperidinedione. This residue was further purified using silica gel column chromatography with a mobile phase consisting of dichloromethane and methanol in a ratio of 100:1. The target product, 2,4-Piperidinedione, was obtained as a white solid, with a yield of 27%, corresponding to 70 mg. |
| | 2,4-Piperadinedione Preparation Products And Raw materials |
|