DELTARASIN HYDROCHLORIDE
中文名称 | DELTARASIN HYDROCHLORIDE |
---|---|
中文同义词 | |
英文名称 | Deltarasin hydrochloride |
英文同义词 | |
CAS号 | 1613404-76-4 |
分子式 | C40H38ClN5O |
分子量 | 640.23 |
EINECS号 | |
相关类别 | |
Mol文件 | 1613404-76-4.mol |
结构式 |
DELTARASIN HYDROCHLORIDE 性质
形态 | 固体 |
---|---|
颜色 | 白色至米白色 |
Kd: 38 nM (PDEδ)
In liver cells, deltarasin inhibits the interaction of RAS with PDEδ with K D of 41 nM. Inhibition of PDEδ-KRAS interaction by deltarasin suppresses proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS.
Deltarasin (10 mg/kg, i.p.) impairs dose-dependent tumor growth in nude mice bearing subcutaneous human Panc-Tu-I tumour cell xenografts.