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ForeChem (Nantong) Technology Co.,Ltd.
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513-85982855 18921614129 |
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sales@xianxingpharm.com |
Products Intro: |
Product Name:1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate CAS:2158302-00-0 Purity:96% Package:10g,500g,1kg,5kg
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| 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Basic information |
| 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Chemical Properties |
| 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Usage And Synthesis |
Chemical Properties | White solid | Synthesis | Dissolve (S)-3-(cyanomethyl)piperazine-1-carboxylic acid tert-butyl ester (2.25g, 10mmol) in 15mL dichloromethane, add N,N-diisopropylethylamine at room temperature (3.87g, 30mmol) was cooled to 0°C, benzyl chloroformate was added dropwise, and reacted at low temperature for 2h. Add 25 mL of water to the reaction solution, extract the aqueous phase with dichloromethane (30 mL×3), combine the organic phases, wash the organic phase with water (20 mL×2), dry with anhydrous sodium sulfate, concentrate, and separate and purify the crude product by silica gel column chromatography (Ethyl acetate/petroleum ether (v/v)=1:20-1:5) to obtain 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate (3.1 g, yield: 86%).
![1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate](/NewsImg/2023-11-01/6383444217863471701418708.jpg) |
| 1-Benzyl 4-(tert-butyl) (S)-2-(cyanomethyl)piperazine-1,4-dicarboxylate Preparation Products And Raw materials |
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