蛙皮素2
中文名称 | 蛙皮素2 |
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中文同义词 | 马盖宁 II;MAGAININ 2抗菌肽;MAGAININ 2肽;定制肽/23肽;蛙皮素 2;GS-23;蛙皮素II;化合物XMD8-92 |
英文名称 | MAGAININ II |
英文同义词 | H-GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-ASN-SER-OH;GLY-ILE-GLY-LYS-PHE-LEU-HIS-SER-ALA-LYS-LYS-PHE-GLY-LYS-ALA-PHE-VAL-GLY-GLU-ILE-MET-ASN-SER;GIGKFLHSAKKFGKAFVGEIMNS;MAGAININ II;MAGAININ 2;96: PN: WO2009015163 SEQID: 98 unclaimed protein;Magainin 2 (Xenopus laevis);Magainin II peptide |
CAS号 | 108433-95-0 |
分子式 | C114H180N30O29S |
分子量 | 2466.9 |
EINECS号 | |
相关类别 | 多肽;生化试剂;抗生素;多肽-客户肽;其他生化试剂;定制肽;Peptide;Immunomodulators and AntibioticsAntibiotics;Antibiotic PeptidesImmune Cell Signaling and Blood;Chemical Structure Class;Immune System Regulation;Immunomodulators;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Peptides;Peptides for Cell Biology;标准品;药物多肽 |
Mol文件 | 108433-95-0.mol |
结构式 |
蛙皮素2 性质
沸点 | 2444.0±65.0 °C(Predicted) |
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密度 | 1.275±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | 溶于二甲基亚砜 |
形态 | 固体 |
颜色 | 白色至米白色 |
序列 | H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Lys-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Asn-Ser-OH |
Magainin 2 exhibits bactericidal effects and induces morphological changes in Escherichia coli regarding early apoptosis. Magainin 2 induces the expression of a bacterial protein with affinity for the caspase substrate and effects the expression of RecA as a caspase-like protein. Magainin 2 kill bacteria by permeabilizing the cell membranes without exhibiting significant toxicity against mammalian cells. The main target of the peptide is considered to be the lipid matrix of the membranes. Application of 10 μg /mL magainin 2 to Paramecium caudatum, a protozoan, in pond water caused an osmotic swelling of the cell and a subsequent cell burst, suggesting that the peptide could perturb membrane functions responsible for osmotic balance. Magainin 2 permeabilizes bacterial and mammalian membranes in significantly different ways. The peptide forms pores with a diameter of about 2.8 nm (less than 6.6 nm) in B. megaterium , and translocates into the cytosol. In contrast, the peptide significantly perturbes the membrane of CHO-K1 cells, permitting the entry of a large molecule (larger than 23 nm) into the cytosol, accompanied by membrane budding and lipid flip-flop, mainly accumulating in mitochondria and nuclei.
纯度(HPLC) ≥98.0%
醋酸根含量≤12.0%
水分含量≤8.0%
肽含量≥80.0%
内毒素≤50EU/mg
氨基酸组成分析≤±10%
安全信息
WGK Germany | 3 |
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提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-P0270 | MAGAININ 2抗菌肽 Magainin 2 | 108433-95-0 | 500μg | 900元 |
2024/04/30 | HY-P0270 | MAGAININ 2抗菌肽 Magainin 2 | 108433-95-0 | 1mg | 1600元 |